IgG4相关性疾病与自身免疫性肝炎的关系

张丽丽; 耿爱文; 亓传旺; 咸建春

doi:10.3969/j.issn.1001-5256.2021.12.050

IgG4相关性疾病与自身免疫性肝炎的关系

DOI: 10.3969/j.issn.1001-5256.2021.12.050

泰州市人民医院肝病科，江苏泰州 225300

基金项目:

江苏省泰州市科技支撑计划(社会发展)项目 (TS201813)

详细信息

通信作者:
亓传旺，qichuanwang1104@163.com

中图分类号: R575
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- 文章访问数: 757
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- 被引次数: 0
出版历程
- 收稿日期: 2021-08-24
- 录用日期: 2021-09-13
- 出版日期: 2021-12-20

Association between immunoglobulin G4-related diseases and autoimmune hepatitis

Department of Hepatopathy, Taizhou People's Hospital, Taizhou, Jiangsu 225300, China

Research funding:

Jiangsu Taizhou Science and Technology Support Plan (Social Development) Project (TS201813)

摘要

摘要: 随着疾病认识及诊疗水平的不断提高，免疫球蛋白G4相关性疾病(IgG4-RD)和自身免疫性肝病的发病率呈上升趋势，IgG4相关性硬化性胆管炎为二者疾病谱的交叉部分，但IgG4相关性自身免疫性肝炎(IgG4-AIH)和二者之间的关系尚不明确。本文回顾了IgG4-RD在肝脏的表现，归纳总结IgG4-AIH的临床特点，并对IgG4-AIH是AIH的一种亚型还是IgG4-RD累及肝脏这一问题进行分析，认为IgG4-AIH与经典AIH的临床表现及组织病理学特点相似而又有不同，IgG4-AIH或许可分为两种类型，即AIH的一种亚型和IgG4-RD的肝脏表现。IgG4-AIH的发病机制、临床特征、临床诊治等方面的研究值得继续关注。
- 免疫球蛋白G /
- 肝炎, 自身免疫性 /
- 自身免疫疾病
Abstract: With the improvement in people's awareness of diseases and the level of diagnosis and treatment, the incidence rates of immunoglobulin G4-related disease (IgG4-RD) and autoimmune liver disease (AILD) are constantly increasing, and IgG4-related sclerosing cholangitis is the overlapping part of the disease spectrum of IgG4-RD and AILD, while the association between IgG4-related autoimmune hepatitis (IgG4-AIH) and these two diseases remains unclear. This article reviews the hepatic manifestation of IgG4-RD, summarizes the clinical features of IgG4-AIH, and analyzes whether IgG4-AIH is a subtype of AIH or a hepatic involvement of IgG4-RD. It is believed that IgG4-AIH has similar but different clinical manifestations and histopathological features from classical AIH, and IgG4-AIH may be classified as two types, i.e., a subtype of AIH and the liver manifestation of IgG4-RD. The research on the pathogenesis, clinical features, and clinical diagnosis and treatment of IgG4-AIH should be taken seriously in future.
- Immunoglobulin G /
- Hepatitis, Autoimmune /
- Autoimmune Diseases

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