细胞焦亡的发生机制及其在肝脏疾病发生发展中的作用

王欣悦; 李德冠

doi:10.3969/j.issn.1001-5256.2021.12.051

细胞焦亡的发生机制及其在肝脏疾病发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2021.12.051

王欣悦,
李德冠^,

中国医学科学院 & 北京协和医学院放射医学研究所，天津市放射医学与分子核医学重点实验室，天津 300192

基金项目:

国家自然科学基金 (81972975)

详细信息

通信作者:
李德冠，lideguan@irm-cams.ac.cn

中图分类号: R575
计量
- 文章访问数: 733
- HTML全文浏览量: 266
- PDF下载量: 68
- 被引次数: 0
出版历程
- 收稿日期: 2021-04-16
- 录用日期: 2021-06-24
- 出版日期: 2021-12-20

Mechanism of pyroptosis and its role in the development and progression of liver diseases

Xinyue WANG,
Deguan LI^,

Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medicine Science & Peking Union Medical College, Tianjin 300192, China

Research funding:

National Natural Science Foundation of China (81972975)

摘要

摘要: 细胞焦亡是一种机体清除内源性和外源性伤害刺激的程序性细胞死亡方式。GSDMD和GSDME是细胞焦亡的主要执行者，属于Gasdermin蛋白家族，可被活化的caspases切割后在细胞膜上穿孔造成细胞内IL-18、IL-1β等炎性因子的释放，发生细胞焦亡。最近研究发现，细胞焦亡参与肝脏疾病的发生发展过程，并在其中发挥“双刃剑”的作用。阐述了细胞焦亡的分子机制以及细胞焦亡在肝脏疾病发生发展中的研究进展，从而为防治肝脏相关疾病提供新的靶点和思路。
- 细胞焦亡 /
- 肝疾病 /
- Gasdermin蛋白
Abstract: Pyroptosis is a pattern of cell death to eliminate endogenous and exogenous harmful stimuli. GSDMD and GSDME, members of the Gasdermin protein family, are the main executors of pyroptosis, and after being cut by activated caspases, they can induce pyroptosis by perforating the cell membrane, and causing the release of intracellular inflammatory factors such as IL-18 and IL-1β. Recent studies have found that pyroptosis is involved and plays a "double-edged sword" role in the development and progression of liver diseases. This article elaborates on the molecular mechanism of pyroptosis and the research advances in the role of pyroptosis in the development and progression of liver diseases, so as to provide new targets and ideas for the prevention and treatment of liver diseases.
- Pyroptosis /
- Liver Diseases /
- Gasdermin protein

HTML全文

图 1 细胞焦亡示意图

注：Death Receptor，死亡受体；Chemotherapy drugs，化疗药物；Virus，病毒；Toxins，毒素；Bacteria，细菌；Cytochrome c，线粒体细胞色素c；Apoptosis，细胞凋亡。

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