白血病抑制因子在胰腺导管腺癌中的作用

谢亚兴; 史晨光; 刘晓欢; 马艳波

doi:10.3969/j.issn.1001-5256.2021.12.053

白血病抑制因子在胰腺导管腺癌中的作用

DOI: 10.3969/j.issn.1001-5256.2021.12.053

1.
山西医科大学第一临床医学院，太原 030000
2.
山西医科大学第一医院普通外科，太原 030000

详细信息

通信作者:
马艳波，15103418205@163.com

中图分类号: R735.9
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- 被引次数: 0
出版历程
- 收稿日期: 2021-04-21
- 录用日期: 2021-05-13
- 出版日期: 2021-12-20

Role of leukemia inhibitory factor in pancreatic ductal adenocarcinoma

1.
The First Clinical Medical College of Shanxi Medical University, Taiyuan 030000, China
2.
Department of General Surgery, The First Hospital of Shanxi Medical University, Taiyuan 030000, China

摘要

摘要: 胰腺导管腺癌是一种高度侵袭性的消化系统恶性肿瘤，其预后极差。白血病抑制因子是IL-6家族的重要成员，可调节细胞的分化、生长和更新等多个生理过程。基于文献证据对白血病抑制因子在胰腺导管腺癌中的作用机制及白细胞抑制因子靶向治疗的研究进展进行综述，分析表明白血病抑制因子在胰腺导管腺癌的发展、免疫逃逸、化疗抵抗等过程中都起着重要作用，并逐渐成为胰腺导管腺癌潜在的生物标志物和治疗靶点。
- 癌, 胰腺管 /
- 白血病抑制因子 /
- 病理过程
Abstract: Pancreatic ductal adenocarcinoma is a highly invasive malignant tumor of the digestive system with an extremely poor prognosis. Leukemia inhibitory factor is an important member of the interleukin-6 family and can regulate multiple physiological processes such as cell differentiation, growth, and renewing. This article reviews the mechanism of action of leukemia inhibitory factor in pancreatic ductal adenocarcinoma and the research advances in leukocyte inhibitory factor-targeted therapy based on literature evidence, and the analysis shows that leukemia inhibitory factor plays an important role in the progression, immune escape, and chemotherapy resistance of pancreatic ductal adenocarcinoma and may gradually become a potential biomarker and therapeutic target for pancreatic ductal adenocarcinoma.
- Carcinoma, Pancreatic Ductal /
- Leukemia Inhibitory Factor /
- Pathologic Processes

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图 1 LIF的JAK/STAT3信号通路

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参考文献(35)

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