胰腺癌肿瘤微环境的机制及靶向治疗

张艺译; 徐敏

doi:10.3969/j.issn.1001-5256.2022.04.046

胰腺癌肿瘤微环境的机制及靶向治疗

DOI: 10.3969/j.issn.1001-5256.2022.04.046

张艺译,
徐敏^, ,

上海交通大学附属第一人民医院消化内科，上海 200080

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：张艺译负责收集资料，分析文献，撰写论文；徐敏负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
徐敏，xumin73@126.com

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出版历程
- 收稿日期: 2021-08-14
- 录用日期: 2021-09-26
- 出版日期: 2022-04-20

Research advances in the mechanism of tumor microenvironment in pancreatic cancer and related targeted therapy

Yiyi ZHANG,
Min XU^{,
,}

Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China

More Information

Corresponding author: XU Min, xumin73@126.com(ORCID: 0000-0003-3224-9348)

摘要

摘要: 胰腺癌肿瘤微环境是一个包含胰腺星状细胞、癌相关成纤维细胞、免疫细胞和细胞外基质的过度纤维化的致密基质环境，不仅为肿瘤创造了促进其生长和侵袭的环境，并使其对化疗和其他抗肿瘤药物产生耐受抵抗。基质中密集纤维化反应和肿瘤在免疫环境中的改变被认为是目前胰腺癌治疗失败的主要原因。本文回顾了近年来胰腺癌肿瘤微环境相关研究进展，对其组成成分和致病机制以及针对基质和免疫的靶向治疗作一综述，分析肿瘤微环境对胰腺癌发生进展的重要性及其在靶向治疗方面的影响。
- 胰腺肿瘤 /
- 肿瘤微环境 /
- 免疫疗法
Abstract: The tumor microenvironment of pancreatic carcinoma is a dense matrix environment with excessive fibrosis containing pancreatic stellate cells, cancer-associated fibroblasts, immune cells, and extracellular matrix, which not only creates an environment to promote the growth and invasion of tumors, but also makes them resistant to chemotherapy and other antitumor drugs. Intensive fibrosis reaction in the matrix and changes of tumors in immune environment are considered the main reasons for treatment failure in pancreatic cancer management. This article reviews the recent research advances in the tumor microenvironment of pancreatic cancer, summarizes its composition and pathogenesis and the targeted therapies for matrix and immune cells, and analyzes the importance of tumor microenvironment in the development and progression of pancreatic cancer and its impact on targeted therapy.
- Pancreatic Neoplasms /
- Tumor Microenvironment /
- Immunotherapy

HTML全文

图 1 胰腺癌TME细胞成分作用机制图

Figure 1. Mechanism of TME cellular components in pancreatic cancer

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