周围神经与胰腺癌细胞之间的代谢交流机制

田庚洲; 邹雷

doi:10.3969/j.issn.1001-5256.2022.12.040

周围神经与胰腺癌细胞之间的代谢交流机制

DOI: 10.3969/j.issn.1001-5256.2022.12.040

田庚洲,
邹雷^, ,

昆明医科大学, 昆明医科大学第一附属医院肝胆外科, 昆明医科大学第一附属医院科研实验中心, 国家卫健委毒品依赖和戒治重点实验室, 昆明 650032

基金项目:

昆医联合专项-杰出青年培育项目 (202101AY070001-032);

基础研究专项-面上项目 (202001AT070018)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：田庚洲、邹雷参与起草论文，并修改文章关键内容。

详细信息

通信作者:
邹雷, zl_8082@126.com

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出版历程
- 收稿日期: 2022-03-30
- 录用日期: 2022-05-19
- 出版日期: 2022-12-20

Research advances in the mechanism of metabolic communication between peripheral nerves and pancreatic cancer cells

Gengzhou TIAN,
Lei ZOU^{,
,}

NHC Key Laboratory of Drug Addiction Medicine; Experimental Research Center of The First Affiliated Hospital of Kunming Medical University; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Kunming Medical University; Kunming Medical University, Kunming 650032, China

Research funding:

Kunming Medical Association Special Project - Outstanding Youth Cultivation Project (202101AY070001-032);

Special Project of Basic Research - General Project (202001AT070018)

More Information

Corresponding author: ZOU Lei, zl_8082@126.com (ORCID: 0000-0001-7515-9073)

摘要

摘要: 肿瘤微环境中各种物质代谢相互联系，代谢信号通路相互作用形成了复杂的代谢网络，共同维持肿瘤微环境的稳态。周围神经由核周体和神经纤维构成的神经干、神经丛、神经节及神经终末装置等组成，在胰腺癌的发展中发挥着关键作用。而目前周围神经与胰腺癌细胞之间代谢交流作用机制的研究相对较少。本文回顾近年来的研究，分别从周围神经和胰腺癌细胞的角度总结了氨基酸、神经递质、神经营养因子等在胰腺癌发展中的作用，认为探讨周围神经和胰腺癌细胞之间的代谢交流机制对发现新的胰腺癌治疗相关靶点有着重要作用。
- 胰腺肿瘤 /
- 周围神经 /
- 代谢网络和途径 /
- 肿瘤侵润
Abstract: The metabolism of various substances is interconnected in tumor microenvironment, and the interaction of metabolic signaling pathways forms a complex metabolic network, which together maintains the homeostasis of tumor microenvironment. Peripheral nerves, which consist of the nerve trunks, plexus, ganglia, and terminals formed by perikaryons and nerve fibers, play a key role in the progression of pancreatic cancer. At present, there are relatively few studies on the mechanism of metabolic communication between peripheral nerves and pancreatic cancer cells. This article reviews recent studies and summarizes the role of amino acids, neurotransmitters, and neurotrophic factors in the progression of pancreatic cancer from the perspectives of peripheral nerves and pancreatic cancer cells, and it is believed that discussion of the mechanism of metabolic communication between peripheral nerves and pancreatic cancer cells may help to discover new targets for pancreatic cancer treatment.
- Pancreatic Neoplasms /
- Peripheral Nerves /
- Metabolic Networks and Pathways /
- Neoplasm Invasiveness

HTML全文

图 1 肿瘤微环境中神经细胞与胰腺癌细胞代谢交流示意图

注：P物质，十一氨基酸多肽；N受体，烟碱型受体；M受体，毒蕈碱型受体；SEMA3D蛋白，轴突引导因子。实线，有促进作用；虚线，有抑制作用。

Figure 1. Metabolic Communication between nerve cells and pancreatic cancer cells in tumor microenvironment

下载: 全尺寸图片幻灯片

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