绿茶提取物可致特异质型肝损伤？——与美国最新版药物性肝损伤指南商榷

高云娟; 赵旭; 朱敬肖; 柏兆方; 王伽伯; 肖小河

doi:10.3969/j.issn.1001-5256.2023.03.007

绿茶提取物可致特异质型肝损伤？——与美国最新版药物性肝损伤指南商榷

DOI: 10.3969/j.issn.1001-5256.2023.03.007

高云娟^{1, 2},
赵旭¹,
朱敬肖^{1, 3},
柏兆方¹,
王伽伯⁴,
肖小河^1, , ,

1.
中国人民解放军总医院第五医学中心肝病医学部，北京 100039
2.
成都中医药大学药学院，成都 611137
3.
国家癌症中心/国家肿瘤临床医学研究中心/河北中国医学科学院肿瘤医院，河北廊坊 065001
4.
首都医科大学中医药学院，北京 100069

基金项目:

国家中医药管理局中医药创新团队及人才支持计划 (ZYYCXTD-C-202005)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：高云娟、朱敬肖负责查询文献，撰写文章；赵旭、柏兆方负责文章关键内容的修改；肖小河、王伽伯指导写作思路。

详细信息

通信作者:
肖小河，pharmacy302xxh@126.com (ORCID：0000-0002-2836-2738)

计量
- 文章访问数: 533
- HTML全文浏览量: 137
- PDF下载量: 107
- 被引次数: 0
出版历程
- 收稿日期: 2022-11-15
- 录用日期: 2022-12-19
- 出版日期: 2023-03-20

Can green tea extract cause specific liver injury?——Discussion of the latest US guidelines on drug-induced liver injury

Yunjuan GAO^{1, 2},
Xu ZHAO¹,
Jingxiao ZHU^{1, 3},
Zhaofang BAI¹,
Jiabo WANG⁴,
Xiaohe XIAO^{1
, ,
,}

1.
Senior Department of Hepatology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China
2.
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
3.
National Cancer Center/National Clinical Research Center for Cancer/Hebei Cancer Hospital, Chinese Academy of Medical Sciences, Langfang, Hebei 065001, China
4.
School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China

Research funding:

Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (ZYYCXTD-C-202005)

More Information

Corresponding author: XIAO Xiaohe, pharmacy302xxh@126.com (ORCID: 0000-0002-2836-2738)

摘要

摘要: 近年来，绿茶提取物的潜在肝毒性越来越多的引起了人们的关注。本文通过现有绿茶提取物肝损伤相关研究，结合最新药物肝毒性分类，对其肝损伤的客观性和成因机制进行了系统的阐述和分析。进一步根据绿茶提取物致肝损伤的主要风险因素，提出了安全合理使用此类产品的相关建议，以期为绿茶提取物肝损伤机制的深入研究和风险的防控提供有价值的见解，同时，也为绿茶提取物改善健康状况的治疗性使用提供重要的参考。
- 化学性与药物性肝损伤 /
- 儿茶酚胺类 /
- 绿茶提取物
Abstract: In recent years, the potential hepatotoxicity of green tea extract (GTE) has attracted more and more attention. With reference to the current studies on liver injury caused by GTE and the latest drug hepatotoxicity classification, this article systematically elaborates on the objectivity and causal mechanisms of liver injury caused by GTE. Based on the main risk factors for liver injury caused by GTE, this article also proposes recommendations for safe and rational use of such products, so as to provide valuable insights for in-depth research on the mechanism of liver injury caused by GTE and risk prevention and control, and meanwhile, it also provides an important reference for the therapeutic use of GTE to improve health conditions.
- Chemical and Drug Induced Liver Injury /
- Catecholamines /
- Green Tea Extract

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参考文献(27)

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