新型血清学指标在评估转氨酶正常的慢性HBV感染者肝病进展中的作用

王源; 刘怀鄂; 丁洁; 王晴晴; 王爱丽; 孙慧; 曹惠

doi:10.3969/j.issn.1001-5256.2023.03.026

新型血清学指标在评估转氨酶正常的慢性HBV感染者肝病进展中的作用

DOI: 10.3969/j.issn.1001-5256.2023.03.026

王源¹,
刘怀鄂^1, , ,,
丁洁²,
王晴晴²,
王爱丽¹,
孙慧¹,
曹惠¹

1.
昆明医科大学第一附属医院感染科，昆明 650032
2.
昆明市第三人民医院肝病综合科，昆明 650032

基金项目:

云南省高层次卫生人才项目 (H-2017071);

云南省教育厅科学研究基金项目 (2021J0239)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：王源负责文献检索及文章撰写；丁洁、王晴晴、王爱丽、孙慧、曹惠负责文献的查找与总结; 刘怀鄂负责文章修改及审定。

详细信息

通信作者:
刘怀鄂，liuhuaie@163.com (ORCID: 0000-0003-0962-2474)

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出版历程
- 收稿日期: 2022-07-12
- 录用日期: 2022-09-02
- 出版日期: 2023-03-20

Role of new serological markers in evaluating the progression of liver disease in patients with chronic HBV infection and normal aminotransferases

1.
Department of Infectious Diseases, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
2.
Department of Hepatology, The Third People's Hospital of Kunming, Kunming 650032, China

Research funding:

Yunnan Province High-level Health Talent Project (H-2017071);

Yunnan Provincial Department of Education Research Fund (2021J0239)

More Information

Corresponding author: LIU Huaie, liuhuaie@163.com (ORCID: 0000-0003-0962-2474)

摘要

摘要: 抗病毒治疗是国内外慢性乙型肝炎管理指南中改善预后的基础治疗措施。但对于转氨酶正常的慢性HBV感染者，准确评价肝炎进展程度，筛选合适的需要抗病毒的患者成为临床难题。为了能够客观、准确的评价此类患者肝脏炎症活动程度，除了开展传统的肝组织活检外，越来越多的无创评估指标被人们所关注。本文将近年来研究中发现的能够反映正常转氨酶水平的慢性HBV感染者肝脏炎症和/或纤维化程度的新型血清学指标进行综述，希望为此类患者抗病毒决策提供参考。
- 乙型肝炎, 慢性 /
- 血清学 /
- 转氨酶类
Abstract: Antiviral therapy is the basic treatment method for improving prognosis recommended in the management guidelines of chronic hepatitis B in China and globally. For patients with chronic HBV infection and normal transaminases, it is difficult in clinical practice to accurately evaluate the progression of hepatitis and identify suitable patients who need antiviral therapy. In order to objectively and accurately evaluate the degree of liver inflammatory activity in such patients, more and more noninvasive evaluation indicators have been used in addition to conventional liver biopsy. This article reviews the new serological indicators that can reflect the degree of liver inflammation and/or fibrosis in patients with chronic HBV infection and normal aminotransferase levels, hoping to provide a reference for antiviral decision-making in these patients.
- Hepatitis B, Chronic /
- Serology /
- Transaminase

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参考文献(43)

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