血清高尔基体蛋白73在非酒精性脂肪性肝病中的作用

张航; 刘近春

doi:10.3969/j.issn.1001-5256.2023.03.028

血清高尔基体蛋白73在非酒精性脂肪性肝病中的作用

DOI: 10.3969/j.issn.1001-5256.2023.03.028

张航¹,
刘近春^2, , ,

1.
山西医科大学研究生院，太原 030001
2.
山西医科大学第一医院消化内科，太原 030001

基金项目:

山西省科技成果转化引导专项项目 (201904D131030)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：张航负责收集文献，撰写论文；刘近春负责拟定写作思路，指导撰写文章，最后定稿。

详细信息

通信作者:
刘近春，zxr610624@163.com (ORCID：0000-0002-1984-6802)

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- 被引次数: 0
出版历程
- 收稿日期: 2022-07-06
- 录用日期: 2022-08-21
- 出版日期: 2023-03-20

Role of serum Golgi protein 73 in nonalcoholic fatty liver disease

Hang ZHANG¹,
Jinchun LIU^{2
, ,
,}

1.
Graduate School of Shanxi Medical University, Taiyuan 030001, China
2.
Department of Gastroenterology, The First Hospital of Shanxi Medical University, Taiyuan 030001, China

Research funding:

Shanxi Province Science and Technology Achievement Transformation Guidance Special Project (201904D131030)

More Information

Corresponding author: LIU Jinchun, zxr610624@163.com (ORCID: 0000-0002-1984-6802)

摘要

摘要: 高尔基体蛋白73是一种可经切割释放入血的高尔基体跨膜蛋白。越来越多的研究表明，血清高尔基体蛋白73的升高与非酒精性脂肪性肝病的发生发展密切相关，有望作为诊断和评估非酒精性脂肪性肝病的潜在血清学标志物。本文就现有研究对血清高尔基体蛋白73在非酒精性脂肪性肝病中的研究进展进行综述，并简析其发挥作用的潜在机制，以期为非酒精性脂肪性肝病的治疗靶点提供新的选择。
- 高尔基体蛋白73 /
- 非酒精性脂肪性肝病 /
- 肝硬化 /
- 血清标志物
Abstract: Golgi protein 73 (GP73) is a Golgi transmembrane protein that can be released into blood by cleavage. An increasing number of studies have shown that the increase in serum GP73 is closely associated with the development and progression of nonalcoholic fatty liver disease (NAFLD) and serum GP73 is expected to be used as a potential serological marker for the diagnosis and assessment of NAFLD. This article reviews the research advances in serum GP73 in NAFLD and analyzes its potential mechanism of action, so as to provide new options for the therapeutic targets of NAFLD.
- Golgi Protein 73 /
- Non-alcoholic Fatty Fiver Disease /
- Liver Cirrohosis /
- Serum Biomarker

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参考文献(40)

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