近红外荧光成像在肝细胞癌肝切除术中的应用

段彦亨; 安家泽

doi:10.3969/j.issn.1001-5256.2023.03.031

近红外荧光成像在肝细胞癌肝切除术中的应用

DOI: 10.3969/j.issn.1001-5256.2023.03.031

段彦亨,
安家泽^, ,

空军军医大学第一附属医院肝胆外科，西安 710032

基金项目:

国家自然科学基金面上项目 (81773177)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：段彦亨负责收集文献，资料分析，撰写论文；安家泽负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
安家泽, anjiaze68@163.com (ORCID: 0000-0002-5839-4992)

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出版历程
- 收稿日期: 2022-06-09
- 录用日期: 2022-07-27
- 出版日期: 2023-03-20

Application of near-infrared fluorescence imaging in hepatectomy of hepatocellular carcinoma

Yanheng DUAN,
Jiaze AN^{,
,}

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China

Research funding:

National Natural Science Foundation of China (General Program) (81773177)

More Information

Corresponding author: AN Jiaze, anjiaze68@163.com (ORCID: 0000-0002-5839-4992)

摘要

摘要: 肝细胞癌(HCC)的治疗是以手术为主的综合治疗，肝切除术需要切除原发性肿瘤并最大限度地保留正常肝组织。然而，在临床手术中，肉眼和触诊难以精确识别肿瘤组织及其边界，往往导致切除不足或过度切除。近红外荧光(NIRF)成像是一种实时、低成本、无创、高灵敏度的成像技术，在引导手术切除肿瘤的应用中得到了广泛的研究。随着荧光成像系统和荧光探针的发展，可以实现术中肿瘤定位和边界确定，使手术更加准确。本文回顾了用于HCC术中导航的各种NIRF探针的发展，并讨论了这些探针的当前挑战和潜在机遇。
- 谱学, 近红外线 /
- 荧光光度测定法 /
- 癌, 肝细胞 /
- 肝切除术
Abstract: Multimodality therapy based on surgery is the main treatment method for hepatocellular carcinoma (HCC), and hepatectomy requires the removal of primary tumor and the preservation of normal liver tissue to the maximum extent. However in clinical surgery, it is difficult to accurately identify tumor tissue and its boundary with visual inspection and palpation, which often results in under-resection or over-resection. Near-infrared fluorescence (NIRF) imaging is a real-time noninvasive imaging technique with low costs and high sensitivity, and extensive studies have been conducted to investigate its application in guiding surgical resection of tumors. With the development of fluorescence imaging system and fluorescence probe, intraoperative tumor localization and boundary determination can be realized to make the surgery more accurate. This article reviews the development of various NIRF probes for intraoperative navigation in HCC and discusses current challenges and potential opportunities of these imaging probes.
- Spectroscopy, Near-Infrared /
- Fluorophotometry /
- Carcinoma, Hepatocellular /
- Hepatectomy

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