重症肝病合并感染的纳米抗菌治疗趋势

罗珍群; 罗新华

doi:10.3969/j.issn.1001-5256.2023.03.036

重症肝病合并感染的纳米抗菌治疗趋势

DOI: 10.3969/j.issn.1001-5256.2023.03.036

罗珍群^{1, 2},
罗新华^2, , ,

1.
遵义医科大学临床医学院，贵州遵义 563000
2.
贵州省人民医院感染科，贵阳 550000

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：罗珍群负责拟定写作思路，查阅文献资料，撰写文章；罗新华负责指导写作思路，修改文章并最后定稿。

详细信息

通信作者:
罗新华，luoxh09@163.com (ORCID: 0000-0002-0323-3868)

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出版历程
- 收稿日期: 2022-07-19
- 录用日期: 2022-09-09
- 出版日期: 2023-03-20

Trends in nano-antimicrobial therapy for severe liver disease with infection

Zhenqun LUO^{1, 2},
Xinhua LUO^{2
, ,
,}

1.
School of Clinical Medicine, Zunyi Medical University, Zunyi, Guizhou 563000, China
2.
Department of Infectious Diseases, Guizhou Provincial People's Hospital, Guiyang 550000, China

More Information

Corresponding author: LUO Xinhua, luoxh09@163.com (ORCID: 0000-0002-0323-3868)

摘要

摘要: 重症肝病合并感染一直是临床治疗的重点难点。研究者们通过对纳米材料的不断探索发现，纳米材料由于其特殊理化性质可实现靶向抗菌及免疫调节作用。从纳米材料无抗生素的靶向抗菌、纳米药物递送系统的靶向抗菌、靶向免疫调节治疗方面，结合新近文献进展对重症肝病合并感染相关的纳米治疗可能机制作一总结，拟为临床上有效治疗重症肝病合并感染提供新的治疗策略。
- 肝疾病 /
- 感染 /
- 纳米粒子
Abstract: Severe liver disease with infection has always been a key and difficult point in clinical treatment. Through continuous exploration of nanomaterials, researchers have found that nanomaterials can achieve targeted antibacterial and immunomodulatory effects due to their special physicochemical properties. With reference to recent articles and advances, this article reviews the possible mechanisms of nano-therapies for severe liver disease with infection from the aspects of targeted antibacterial effect of nanomaterials without antibiotics, targeted antibacterial effect of nano-drug delivery systems, and targeted immunomodulatory therapy, so as to provide new treatment strategies for the prevention and treatment of severe liver disease with infection in clinical practice.
- Liver Diseases /
- Infection /
- Nanoparticles

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