激酶锚定蛋白12在慢性肝病中的作用

董海舰; 李晖; 陶雨静; 郭佳玲; 钟宇汝; 曾子键

doi:10.3969/j.issn.1001-5256.2023.03.037

激酶锚定蛋白12在慢性肝病中的作用

DOI: 10.3969/j.issn.1001-5256.2023.03.037

董海舰^{1, 2},
李晖^1, , ,,
陶雨静^{1, 2},
郭佳玲^{1, 2},
钟宇汝^{1, 2},
曾子键^{1, 2}

1.
成都中医药大学附属医院中心实验室，成都 610072
2.
成都中医药大学临床医学院，成都 610072

基金项目:

四川省科技厅项目 (2020YFS0379)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：董海舰负责撰写论文；陶雨静、郭佳玲、钟宇汝、曾子键参与收集文献，修改论文；李晖负责拟定写作思路，指导文章撰写并最后定稿。

详细信息

通信作者:
李晖，1400124746@qq.com (ORCID: 0000-0002-5919-1396)

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- 被引次数: 0
出版历程
- 收稿日期: 2022-07-06
- 录用日期: 2022-08-08
- 出版日期: 2023-03-20

Role of A-kinase anchor protein 12 in chronic liver diseases

Haijian DONG^{1, 2},
Hui LI^{1
, ,
,},
Yujing TAO^{1, 2},
Jialing GUO^{1, 2},
Yuru ZHONG^{1, 2},
Zijian ZENG^{1, 2}

1.
Central Laboratory, The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China
2.
School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China

Research funding:

Sichuan Science and Technology Program (2020YFS0379)

More Information

Corresponding author: LI Hui, 1400124746@qq.com (ORCID: 0000-0002-5919-1396)

摘要

摘要: 激酶锚定蛋白(AKAP)12是一种支架蛋白，通过将细胞内信号蛋白组装成特定的复合体来提高时空信号的特异性和效率。近年来，AKAP12在慢性肝病中的作用越来越受到关注。本文介绍了AKAP12的生理功能，并对AKAP12在慢性肝病中的作用进行了总结，以期为AKAP12小分子作为新的慢性肝病治疗靶点研究奠定基础。
- A型激酶锚定蛋白质类 /
- 肝硬化 /
- 非酒精性脂肪性肝病 /
- 肝疾病, 酒精性 /
- 癌, 肝细胞
Abstract: A-kinase anchor protein 12 (AKAP12) is a scaffold protein that improves the specificity and efficiency of spatio-temporal signals by assembling intracellular signal proteins into specific complexes. In recent years, the role of AKAP12 in chronic liver diseases has attracted more and more attention. This article introduces the physiological functions of AKAP12 and reviews the role of AKAP12 in chronic liver diseases, in order to lay a foundation for the use of AKAP12 small molecule as a new therapeutic target for chronic liver diseases.
- A Kinase Anchor Proteins /
- Liver Cirrhosis /
- Non-alcoholic Fatty Liver Disease /
- Liver Diseases, Alcoholic /
- Carcinoma, Hepatocellular

HTML全文

图 1 AKAP12调控有丝分裂的过程

Figure 1. The process of AKAP12 regulating mitosis

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