T淋巴细胞在原发性硬化性胆管炎中的作用
DOI: 10.3969/j.issn.1001-5256.2023.12.026
利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:李子怡、毛小荣、李俊峰对文章的思路和设计有关键贡献,并参与修改文章关键内容;李子怡、张万洁、王富春均参与了文献检索及起草文章初稿。
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摘要: 原发性硬化性胆管炎(PSC)是一种免疫介导的慢性胆汁淤积性肝病,可进展为肝硬化和肝衰竭等终末期肝病,目前尚无有效的治疗方法。研究发现,T淋巴细胞与PSC的发生发展密切相关。现对T淋巴细胞在PSC中的作用进行综述,以期为PSC发病机制的研究及临床诊疗提供新的思路。Abstract: Primary sclerosing cholangitis (PSC) is an immune-mediated chronic cholestatic liver disease and can progress to end-stage liver diseases such as liver cirrhosis and liver failure, and there are still no effective treatment methods at present. Studies have found that T lymphocytes are closely associated with the development and progression of PSC. This article reviews the role of T lymphocytes in PSC, so as to provide new ideas for research on the pathogenesis of PSC and the clinical diagnosis and treatment of PSC.
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Key words:
- T lymphocytes /
- Primary Sclerosing Cholangitis /
- Pathogenesis
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