N7-甲基鸟苷（m<sup>7</sup>G）在肝细胞癌中的作用机制

高春; 江晶晶; 陈玉春; 于晓辉; 张久聪; 郑晓凤

doi:10.3969/j.issn.1001-5256.2023.12.029

N7-甲基鸟苷（m⁷G）在肝细胞癌中的作用机制

DOI: 10.3969/j.issn.1001-5256.2023.12.029

高春¹,
江晶晶²,
陈玉春²,
于晓辉²,
张久聪^2, , ,,
郑晓凤^3, , ,

1.
甘肃中医药大学第一临床医学院，兰州 730000
2.
中国人民解放军联勤保障部队第九四〇医院消化内科，兰州 730050
3.
兰州大学第二医院消化内科，兰州 730030

基金项目:

甘肃省自然科学基金 (21JR7RA002);

甘肃省自然科学基金 (22JR5RA1012);

中央高校优秀青年团队培育项目 (31920220065);

兰州市青年科技人才创新重点项目 (2023-2-29)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：高春负责论文撰写与修改；江晶晶、陈玉春等负责论文修改和审阅；郑晓凤负责数据收集；张久聪、于晓辉等负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
张久聪， zhangjiucong@163.com （ORCID： 0000-0003-4006-3033）

郑晓凤， zhengxf19892013@126.com （ORCID： 0009-0002-9660-1224）

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- 文章访问数: 228
- HTML全文浏览量: 68
- PDF下载量: 27
- 被引次数: 0
出版历程
- 收稿日期: 2023-03-15
- 录用日期: 2023-03-27
- 出版日期: 2023-12-12

Mechanism of action of N7-methylguanosine in hepatocellular carcinoma

1.
The First Clinical Medical College of Gansu University of Chinese Medicine，Lanzhou 730000，China
2.
Department of Gastroenterology，The 940 Hospital of Joint Logistic Support Force of PLA，Lanzhou 730050，China
3.
Department of Gastroenterology，The Second Hospital of Lanzhou University，Lanzhou 730030，China

Research funding:

Gansu Natural Science Foundation (21JR7RA002);

Gansu Natural Science Foundation (22JR5RA1012);

Central University Excellent Youth Team Cultivation Project (31920220065);

Lanzhou Youth Science and Technology Talent Innovation Key Project (2023-2-29)

More Information

Corresponding author: ZHANG Jiucong， zhangjiucong@163.com （ORCID： 0000-0003-4006-3033）； ZHENG Xiaofeng， zhengxf19892013@126.com （ORCID： 0009-0002-9660-1224）

摘要

摘要: N7-甲基鸟苷（m⁷G）是目前最流行的RNA修饰之一，最近引起了国内外学者极大的关注。m⁷G修饰通过影响各种RNA分子（包括信使RNA、核糖体RNA、微RNA和转移RNA）的代谢，积极参与细胞的增殖、分化和凋亡等多种生物学过程。越来越多的证据表明，m⁷G尤其在癌症中起着关键作用，异常的m⁷G水平通过调节多个癌基因和抑癌基因的表达与肿瘤的发生和发展密切相关。肝细胞癌是我国最常见的消化道肿瘤，治疗效果欠佳。目前，肝细胞癌中m⁷G修饰的潜在分子机制尚不完全清楚。本文就m⁷G修饰在肝细胞癌中的潜在作用机制，以及m⁷G相关的诊断和治疗策略进行综述。
- 癌，肝细胞 /
- N7-甲基鸟苷 /
- 甲基化
Abstract: N7-methylguanosine （m⁷G） is one of the most popular RNA modifications at present and has attracted wide attention from researchers in China and globally. By influencing the metabolism of various RNA molecules （including messenger RNA， ribosomal RNA， microRNA， and transfer RNA）， m⁷G modification actively participates in many biological processes such as cell proliferation， differentiation， and apoptosis. More and more evidence has shown that m⁷G plays a key role in the development of cancer， and abnormal m⁷G levels are closely associated with the development and progression of cancer by regulating the expression of multiple oncogenes and tumor suppressor genes. Hepatocellular carcinoma is the most common gastrointestinal tumor in China， and current treatment methods tend to have an unsatisfactory therapeutic effect. At present， the potential molecular mechanism of m⁷G modification in hepatocellular carcinoma remains unclear. This article reviews the potential mechanism of action of m⁷G modification in hepatocellular carcinoma and the m⁷G-related diagnosis and treatment strategies.
- Carcinoma， Hepatocellular /
- N7-methylguanosine /
- Methylation

HTML全文

图 1 m⁷G的结构及修饰

Figure 1. Structure and modification of m⁷G

下载: 全尺寸图片幻灯片

图 2 m⁷G MeRIP seq、m⁷G seq检测技术的比较

Figure 2. Comparison of m⁷G MeRIP seq and m⁷G seq detection techniques

下载: 全尺寸图片幻灯片

图 3 m⁷G修饰防止核糖体在m⁷G tRNA解码密码子处停滞

Figure 3. m⁷G modification prevents ribosome stagnation at the m⁷G tRNA decoding codon

下载: 全尺寸图片幻灯片

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