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姓名: 张丽军
职称: 研究员
单位: 上海市公共卫生临床中心 科研中心
简历介绍:

博士、研究员、复旦大学硕士生导师,上海市金山区青年拔尖人才,中南大学药学博士后,美国布法罗大学访问学者。上海市公共卫生临床中心I期临床试验研究室实验室主任。CNHUPO委员会理事,药理学学会分析药理学会青年委员。

主持国家自然科学基金、上海市自然科学基金、上海市卫生计生委重点课题、中国博士特别基金、王宝恩肝纤维化基金等课题8项。以子课题负责人身份参与863课题、十二五重大新药创制项目、十二五传染病专项和973 课题等国家级课题5项。

参与组建了I期临床试验研究室并通过了CFDA认证,负责的I期实验室通过国家认可委ISO17025认可。

第一作者或者通讯作者发表SCI论文20篇,获授权发明专利3项,获第二十五届上海市优秀发明选拔赛银奖。作为CO-PI完成5项I期临床试验,现作为PI助理完成200多项I期临床试验。

发表的部分科研论文(2010年后):

1)Zhang Y1, Shen Y1, Yin L1, Qi T1, Jia X1, Lu H1, Zhang L1. Plasma membrane proteomic profile discovers macrophage-capping protein related to latent HIV-1. Curr HIV Res. 2019 May 6.(通讯作者);

2)Wan-jie, Niu   Tao, Sun   li, Liu   Xiao-qian, Liu   Ren-fang, Zhang   Lin, Yin   Jiang-rong, Wang   Xiao-fang, Jia   Hong-Zhou, Lu   Ming-kang, Zhong   Zheng, Jiao*, Li-jun, Zhang*. Population pharmacokinetics and dosing regimen optimisation of lopinavir in Chinese adults infected with HIV. Basic & Clinical Pharmacology & Toxicology, 2019(通讯作者);

3)Ao Wu1,2, Jiaoli Zhang1, Liyan Zeng2, Feng Li2, Zhaoguang Dong2, Yanling Feng2, Xiaofang Jia2,Jun-O Jin2, and Lijun Zhang1,2*. Upregulation of breast cancer resistance protein expression was decreased in plasma membrane of colon cancer with metastasis of lymphatic node. Clinical Laboratory 2018 (通讯作者);

4)Zhimi Tan, Xiaofang Jia, Fang Ma, Yanling Feng, Hongzhou Lu, Jun-O Jin, Dage Wu, Lin Yin, Li Liu, Lijun Zhang*. Increased MMAB level in mitochondria as a novel biomarker of hepatotoxicity induced by Efavirenz. Plos one 2017 (通讯作者);

5)Tao Sun, Li Liu, Ao Wu, Yujiao Zhang, Xiaofang Jia, Lin Yin, Hongzhou Lu*,1 , Lijun Zhang*,1. iTRAQ based investigation of plasma proteins in HIV infected and HIV/HBV coinfected patients - C9 and KLK are related to HIV/HBV coinfection. Int J Infect Dis. 2017, 63: 64-71(通讯作者);

6)Xiaofang Jia1, Li Liu1, Xiaoqian Liu1, Dage Wu1, Lin Yin1, Xiaohui Liu2, Jiaoli Zhang1, Pengyuan Yang2, Hongzhou Lu1*,and Lijun Zhang1.Vimentin—a potential biomarker for therapeutic efficiency of HAART. Acta Biochim Biophys Sin 2014 Nov;46(11):1001-6 (通讯作者) ;

7)ZHAO QianQian1, FENG YanLing1, JIA XiaoFang1, YIN Lin1, ZHENG Ye1, OUYANG DongSheng2, ZHOU HongHao2* & ZHANG LiJun1,2*. Proteome analysis of hepatic non-parenchymal cells of immune liver fibrosis rats. Sci China Life Sci March (2014) Vol.57 No.3: 303–314 (通讯作者);

8)Ming-Yi Xu,Xiao-Fang Jia,Ying Qu, Rui-Dan Zheng,Zheng-Hong Yuan, Hong-Lei Weng,Steven Dooley, Xing-Peng Wang, Li-Jun Zhang*,Lun-Gen Lu*. Serum dihydroxyacetone kinase peptide m/z 520.3 as predictor of disease severity in patients with compensated chronic hepatitis B. Journal of Translational Medicine,11:234,2013 (并列通讯作者);

9)Jia X, Yin L, Feng Y, Peng X, Ma F, Yao Y, Liu X, Zhang Z, Yuan Z, Zhang L. A dynamic plasma membrane proteome analysis of alcohol-induced liver cirrhosis. Proteome Sci. 2012 Jun 8;10(1):39. (通讯作者);

10)Yingqi Hua,Xiaofang Jia,Mengxiong Sun,Longpo Zheng, Lin Yin, Lijun Zhang*, Zhengdong Cai*. Plasma membrane proteomic analysis of human osteosarcoma and osteoblastic cells: revealing NDRG1 as a marker for osteosarcoma. Tumor Biol. 2011, 32(5):1013-21 (IF 2.026)(并列通讯作者);

11)Lijun Zhang*,Xiaofang Jia,Xiaojun Zhang,Jing Cao,Pengyuan Yang, Chao Qiu, Yinzhong Shen, Fang Ma, Li Liu, Jianjun Sun, Fang Shen, Lin Yin, Liwen Liu, Yamin Yao, Hongzhou Lu*. Alpha-1 antitrypsin variants in plasma from HIV-infected patients revealed by proteomic and glycoproteomic analysis. Electrophoresis (IF3.077) 2010,31 (20): 3437-3446(第一作者和并列通讯作者);

12)Lijun Zhang*, Xiaofang Jia*, Xiaojun Zhang, Jianjun Sun, Xia Peng, Tangkai Qi,Fang Ma, Lin Yin , Yamin Yao, Chao Qiu, Hongzhou Lu*. Proteomic analysis of PBMCs: characterization of potential HIV-associated proteins. Proteome Science(IF2.56) 2010, 8:12(第一作者和并列通讯作者);

13)Lijun Zhang*, Xiaofang Jia, Xia Peng, Chao Qiu, Qiang Ou, Yamin Yao, Fang Shen, Hua Yang, Xiuhua Peng, Zhenghong Yuan*. Development and validation of a liquid chromatography-mass spectrometry metabonomic platform in human plasma of liver failure caused by Hepatitis B Virus. Acta Biochimica et Biophysica Sinica(IF1.48). 2010,42(10):688-698(第一作者和并列通讯作者);

14)Lijun Zhang*, Xiaofang Jia*, Yanling Feng, Xia Peng, Zhiyong Zhang, Wenjiang Zhou, Zhanqing Zhang, Fang Ma, Xiaohui Liu, Ye Zheng, Pengyuan Yang and Zhenghong Yuan*. Plasma membrane proteome analysis of the early effect of alcohol on liver: implications for alcoholic liver disease. Acta Biochimica et Biophysica Sinica(IF1.48),2011,43(1):19-29(第一作者和并列通讯作者);

15)Lijun Zhang*, Xia Peng, Zhanqin Zhang, Yanling Feng, Xiaofang Jia, Yuxin Shi, Hua Yang, Zhiyong Zhang, Xiaonan Zhang, Liwen Liu, Lin Yin, Zhenghong Yuan*. Subcellular proteome analysis unraveled Annexin A2 related to immune liver fibrosis. Journal of cellular biochemistry(IF2.94). 2010,110(1):219-228(第一作者和并列通讯作者).

16)Zhiyu Zhan, Lijun Zhang*, Yingqi Hua, Xiaofang Jia, Jian Li, Shuo Hu, Xia Peng, Pengyuan Yang, Mengxiong Sun, Fang Ma,Zhengdong Cai*. Comparative proteomic analysis of plasma membrane proteins between human osteosarcoma and normal osteoblastic cell lines. BMC cancer(IF2.74). 2010, 10:206-215 (并列通讯作者)。

授权专利:

1)专利号:ZL201110439824.5.发明名称:艾滋病病毒感染的诊断标记Talin-1片段及其应用。发明人:张丽军、贾小芳、马芳、姚亚敏、卢洪洲;

2)专利申请号:ZL201110366184.X.发明名称:膜联蛋白A3在检测酒精性肝纤维化中的用途。发明人:张丽军、袁正宏、马芳、贾小芳、姚亚敏、刘晓茜;

3)专利申请号:2015106440141.发明名称:钴巴啉酸二酰胺腺苷三磷酸钴胺素腺苷转移酶的药用用途。发明人:张丽军,贾小芳,卢洪洲,尹林。


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