郑州大学第一附属医院消化内科,副主任医师,副教授,硕士生导师。中华医学会消化病分会青年委员,河南省医学会消化病分会委员。
研究方向:胰腺疾病的基础与临床,承担国家自然科学基金2项,河南省医学科技攻关计划重点项目1项。
2010年首批入选河南省卫生科技创新型人才工程中青年科技创新人才;2012年入选“郑州大学重点学科振兴行动计划青年人才培养对象”;2012年荣获“河南省卫生科技突出贡献奖”。参与研究项目“胰腺癌癌基因的鉴定与临床应用”获2012年教育部科技进步二等奖及上海市科技进步二等奖。
承担课题:
1. 国家自然科学基金(青年基金项目):胰腺腺泡细胞介导REG Ialpha在胰腺导管腺癌发病中的作用及机制研究 (编号:81001103)。
2. 国家自然科学基金(面上项目):肿瘤低氧微环境下ACE- Ang (1-7) -Mas轴功能缺失在胰腺癌发病中的作用及机制研究(编号:81472325)。2015.01-2018.12.
近5年在学术期刊上发表的文章:
1. Zhou L, Zhang R, Zhang L, Sun Y, Yao W, Zhao A, Li J, Yuan Y. Upregulation of Transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer. Cancer Sci, 2013, 104(4): 423-430. (IF=3.479)
2. Zhang R, Ying K, Shi L, Zhang L, Zhou L*. Combined endobronchial and endoscopic ultrasound-guided fine needle aspiration for mediastinal lymph node staging of lung cancer: A meta-analysis. Eur J Cancer, 2013, 49(8): 1860-1867. (*corresponding author) (IF=5.061)
3. Zhou L, Zhang R, Zhang L, Yao W, Li J, Yuan Y. Angiotensin-converting enzyme 2 acts as a potential molecular target for pancreatic cancer therapy. Cancer Lett, 2011, 307(1):18-25. (IF=4.258)
4. Zhou L, Zhang R, Wang L, Shen S, Okamoto H, Sugawara A, Xia L, Wang X, Noguchi N, Yoshikawa T, Uruno A, Yao W, Yuan Y. Upregulation of REG Ialpha accelerates tumor progression in pancreatic cancer with diabetes. Int J Cancer. 2010, 127(8): 1795-803. (IF=6.198)
5. Zhou L, Zhang R, Yao W, Wang J, Qian A, Qiao M, Zhang Y, Yuan Y. Decreased expression of Angiotensin-converting enzyme 2 in pancreatic ductal adenocarcinoma is associated with tumor progression. Tohoku J Exp Med. 2009, 217(2): 123-31. (IF=1.367)
6. Zhang R, Zhou L*, Li Q, Liu J, Yao W, Wan H. Up-regulation of Two Actin Associated Proteins Prompts Pulmonary Artery Smooth Muscle Cell Migration Under Hypoxia. Am J Respir Cell Mol Biol. 2009, 41(4): 467-75. (*Co-first author) (IF=4.148)
7. Zhang RF, Zhou L, Ma GF, Shao FC, Wu XH, Ying KJ. Diagnostic value of transthoracic Doppler Echocardiography in pulmonary hypertension: a meta-analysis. Am J Hypertens. 2010, 23(12):1261-4. (IF=3.665)
8. Zhang R, Shi L, Zhou L, Zhang G, Wu X, Shao F, Ma G, Ying K.Transgelin as a Therapeutic Target to Prevent Hypoxic Pulmonary Hypertension. Am J Physiol Lung Cell Mol Physiol.2014 Jan 24. [Epub ahead of print] (IF=3.523)
9. Zhang R, Wu Y, Zhao M, Liu C, Zhou L, Shen S, Liao S, Yang K, Li Q, Wan H. Role of HIF-1 alpha in the regulation on ACE and ACE2 expression in hypoxia human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2009; 297(4): L631-40. (IF=3.523)
10. Qian AH, Liu XQ, Yao WY, Wan HY, Sun J, Zhou L, Yuan YZ. Voltage-gated potassium channels in IB4-positive colonic sensory neurons mediate visceral hypersensitivity in the rat. Am J Gastroenterol. 2009; 104(8): 2014-27. (IF: 7.553)
11. He X, Zheng Z, Li J, Ben Q, Liu J, Zhang J, Ji J, Yu B, Chen X, Su L, Zhou L, Liu B, Yuan Y. DJ-1 Promotes Invasion and Metastasis of Pancreatic Cancer Cells by Activating SRC/ERK/uPA. Carcinogenesis. 2012; 33(3): 555-62. (IF: 5.635)
12. 周琳,姚玮艳,张连峰,章永平,乔敏敏,袁耀宗.Transgelin在伴随糖尿病的胰腺癌中的表达及其对SW1990细胞运动侵袭的影响.中华消化杂志,2011, 31(9):604-608.
13. 周琳,张连峰,姚玮艳,章永平,乔敏敏,袁耀宗.血管紧张素转化酶II与血管紧张素转化酶在胰腺癌组织中的表达水平变化及相互关系.胃肠病学和肝病学杂志,2011,20(7):671-674.
14. 周琳,张连峰,李伟芳,史成章.血管紧张素转化酶II对吉西他滨治疗胰腺癌细胞株敏感性的影响.胃肠病学和肝病学杂志,2011;20(6):576-578.
15. 周琳,张连峰,孙玉岭.靶向封闭再生基因I对胰腺癌细胞SW1990增殖行为的影响.中华临床医师杂志,2011;5(11):3132-3136.
16. 周琳,袁耀宗.新发糖尿病与胰腺癌的早期诊断.中华糖尿病杂志,2009, 1(8):301-303.