张小勇，现任南方医科大学南方医院感染内科教授，博士生导师，中华医学会感染病学分会青年委员会副主任委员。华中科技大学同济医学院医学博士，德国杜伊斯堡-埃森大学医学博士、博士后。主要致力于乙型肝炎病毒免疫致病机制和抗病毒治疗的研究，重点关注宿主基因与HBV感染之间的相互作用及抗病毒新靶标的筛选与临床开发。作为负责人承担国家自然科学基金4项和多项省部级课题，国家“十三五”传染病防治重大专项和广州市健康医疗协同创新重大专项子课题负责人，入选广东省“特支计划”青年拔尖人才和广州市“珠江科技新星”。 研究成果在国内外期刊发表SCI科研论文50余篇，其中第一和通讯作者论文19篇，总影响因子>100。研究成果在国际肝病会议和国际乙肝分子生物学会议等国际会议上口头汇报10余次，连续多次获得欧洲肝病研究联合会（EASL）和亚太地区肝病联合会（APASL）的“青年科学家”奖励。

1.Zhu W, Liu H, Zhang X*. Toward Curative Immunomodulation Strategies for Chronic Hepatitis B Virus Infection. ACS Infect Dis. 2019 May 10;5(5):703-712.

2.Chen Z, Chen J, Huang X, Wu Y, Huang K, Xu W, Xie L, Zhang X*, Liu H. Identification of Potential Key Genes for Hepatitis B Virus-Associated Hepatocellular Carcinoma by Bioinformatics Analysis. J Comput Biol. 2019 May;26(5):485-494.

3.Zide Chen, Jiehua Chen, Hongyan Liu, Wei Dong, Xuan Huang, Dajun Yang, Jinlin Hou, Xiaoyong Zhang*. The SMAC mimetic APG-1387 sensitizes immune-mediated cell apoptosis in hepatocellular carcinoma Front. Pharmacol. DOI: 10.3389/fphar.2018.01298

4.Hongyan Liu, Jinlin Hou, Xiaoyong Zhang*. Targeting cIAPs, A New Option for Functional Cure of Chronic Hepatitis B Infection? Virologica Sinica. DOI: 10.1007/s12250-018-0062-x.

5.Chen H, He G, Chen Y, Zhang X*, Wu S. Differential Activation of NLRP3, AIM2, and IFI16 Inflammasomes in Humans with Acute and Chronic Hepatitis B. Viral Immunol. 2018 Sep 15. doi: 10.1089/vim.2018.0058.

6.Liu H#, Li F#, Zhang X#, Yu J, Wang J, Jia J, Yu X, Shen Z, Yuan Z, Zhang X, Zhang Z, Zhang X, Lu L, Li H, Lu M, Zhang J. Differentially expressed intrahepatic genes contribute to control of hepatitis B virus replication in the inactive carrier phase. J Infect Dis. 2018 Mar 13;217(7):1044-1054. doi: 10.1093/infdis/jix683.

7.Ge J#, Huang Z#, Liu H#, Chen J, Xie Z, Chen Z, Peng J, Sun J, Hou J, Zhang X*. Lower Expression of MicroRNA-155 Contributes to Dysfunction of Natural Killer Cells in Patients with Chronic Hepatitis B. Front Immunol. 2017 Sep 22;8:1173. doi: 10.3389/fimmu.2017.01173.

8.Liu C #, Huang X #, Werner M, Broering R, Ge J, Li Y, Liao B, Sun J, Peng J, Lu M, Hou J *, Zhang X *. Elevated Expression of Chemokine CXCL13 in Chronic Hepatitis B Patients Links to Immune Control during Antiviral Therapy. Front Immunol. 2017 Mar 23;8:323. doi: 10.3389/fimmu.2017.00323.

9.Deng G #, Ge J #, Liu C, Pang J, Huang Z, Peng J, Sun J, Hou J *, Zhang X *. Impaired expression and function of TLR8 in chronic HBV infection and its association with treatment responses during peg-IFN-α-2a antiviral therapy. Clin Res Hepatol Gastroenterol. 2017 Feb 21. pii: S2210-7401(17)30005-0. doi: 10.1016/j.clinre.2016.12.006.

10.Pang J #, Zhang G #, Lin Y, Xie Z, Liu H, Tang L, Lu M, Yan R, Guo H, Sun J, Hou J *, Zhang X *. Transforming growth factor β-activated kinase 1 transcriptionally suppresses hepatitis B virus replication. Sci Rep. 2017 Jan 3;7:39901. doi: 10.1038/srep39901.

11.Zhang X #, Liu H #, Xie Z, Deng W, Wu C, Qin B, Hou J, Lu M *. Epigenetically regulated miR-449a enhances hepatitis B virus replication by targeting cAMP-responsive element binding protein 5 and modulating hepatocytes phenotype. Sci Rep. 2016 May 3;6:25389. doi: 10.1038/srep25389.

12.Liu HY, Zhang XY *. Innate immune recognition of hepatitis B virus. World J Hepatol. 2015 Sep 28;7(21):2319-22. doi: 10.4254/wjh.v7.i21.2319.

13.Huang Z#, Ge J#, Pang J, Liu H, Chen J, Liao B, Huang X, Zuo D, Sun J, Lu M, Zhang X *, Hou J *. Aberrant expression and dysfunction of TLR2 and its soluble form in chronic HBV infection and its regulation by antiviral therapy. Antiviral Res. 2015 Jun;118:10-19. doi: 10.1016/j.antiviral.2015.03.004.

14.Zhang X, Hou J., Lu M, Regulation of Hepatitis B virus Replication by Epigenetic Mechanisms and MicroRNAs. Front. Genet. 2013, Oct 14;4:202

15.Meng Z #, Zhang X #, Wu J, Pei R, Xu Y, Yang D, Roggendorf M, Lu M * RNAi Induces Innate Immunity through Multiple Cellular Signaling Pathways. PLoS One. 2013 May 20;8(5):e64708. doi: 10.1371/journal.pone.0064708. Print 2013.

16.Zhang X., Ma Z., Liu H., Liu J., Meng Z., Boering R., Yang D., Schlaak J., Roggendorf M., and Lu M, Role of Toll-like receptor 2 in the immune response against Hepadnavirus infection. J Hepatol. 2012, vol. 57, 522-528.

17.Zhang X *, Kraft A., Boering R., Schlaak J., Dittmer U., and Lu M *, Preclinical development of TLR ligands as drugs for the treatment of chronic viral infections. Expert Opin Drug Discov, 2012 Jul;7(7):597-611.

18.Zhang X , Zhang E., Ma Z., Pei R., Jiang M., Schlaak J., Roggendorf M., and Lu M. Modulation of HBV Replication and Hepatocyte Differentiation by MicroRNA-1. Hepatology, 2011; 53(5):1476-1485.

19.Zhang X#, Meng Z#, Qiu S., Xu Y., Wu J., Schlaak J., Roggendorf M., and Lu M *. Lipopolysaccharide Inhibit Woodchuck Hepatitis Virus Replication in Primary Hepatocytes via Interferon-independent Pathways. Cell Microbiol, 2009; 11(11), 1624–1637.