复旦大学附属华山医院胰腺外科主任、复旦大学胰腺病研究所所长，上海市医学领军人物、上海市优秀学科带头人。上海市中西医结合学会胰腺疾病专委会主任委员；上海市抗癌协会胰腺癌专业委员会副主任委；上海市社会医疗机构协会肿瘤学分会胰腺肿瘤多学科专业委主任委员。  中华医学会肿瘤分会胰腺肿瘤学组副组长；中华医学会普外科分会胰腺学组委员；中国抗癌协会胰腺癌专业委员会副主任委员；中国临床肿瘤学会（CSCO）胰腺癌专家委员会副主任委员；中国医促会胰腺病专委会副主任委员；中国医药教育协会腹部肿瘤专业委员会快速康复学组副主任委员。

主要从事胰腺癌分子生物发病机制、早期诊断和综合治疗的基础和临床研究，开展“胰腺癌分阶段综合治疗”、“可切除胰腺癌多时相介入化疗”、“胰腺癌淋巴转移特性及干预研究”、“胰腺癌精准手术治疗研究”、“胰腺疾病微创治疗研究”等创新的临床特色研究。

近3年以第一作者或通讯作者身份在国内外发表的论文及专著，国内获奖情况，承担的科研项目。

科研项目：

1、2023.1～2026.12 国家自然科学基金面上项目(项目批准号：82273426)：胰腺癌外泌体通过C1QBP/IGF-1通路诱导肝脏巨噬细胞活化促进胰腺癌肝转移的机制研究。

2、2020.12.1～2022.9.30 胰腺癌专病队列数据库与全生命周期生物样本库建设（SHDC220CR5008,参与单位之一，40万）

3、2018-2023 中德科学中心 CZ1456：胰腺癌精准治疗。

发表论文:

1.Xie ZB, Yao L, Jin C, Zhang YF, Fu DL .High cytoplasm HABP1 expression as a predictor of poor survival and late tumor stage in pancreatic ductal adenocarcinoma patients. Eur J Surg Oncol. 2019 ;45(2):207-212. doi: 10.1016/j.ejso.2018.09.020. Epub 2018 Oct 21.

2.LyP-1-fMWNTs enhanced targeted delivery of MBD1siRNA to pancreatic cancer cells. Lin QJ, Xie ZB, Gao Y, Zhang YF, Yao L, Fu DL. J Cell Mol Med. 2020 ;24(5):2891-2900. doi: 10.1111/jcmm.14864. 

3.Meta-analysis of Ki-67 expression for recurrence in patients with solid pseudopapillary tumor of the pancreas. Zou C, Yang F, Fu D.HPB (Oxford). 2020 ;22(4):631-632. doi: 10.1016/j.hpb.2019.09.018. 

4.Ki-67 and malignancy in solid pseudopapillary tumor of the pancreas: A systematic review and meta-analysis. Zou C, Yang F, Wu W, Fu D. Pancreatology. 2020 ;20(4):683-685. doi: 10.1016/j.pan.2020.03.015. 

5.WD repeat-containing protein 1 maintains β-Catenin activity to promote pancreatic cancer aggressiveness. Li H, Liu X, Jiang S, Zhou X, Yao L, Di Y, Jiang Y, Gu J, Mao Y, Li J, Jin C, Yang P, Fu D. Br J Cancer. 2020 ;123(6):1012-1023. doi: 10.1038/s41416-020-0929-0.

6.Single-nucleotide polymorphisms based genetic risk score in the prediction of pancreatic cancer risk. Wang XY, Chen HT, Na R, Jiang DK, Lin XL, Yang F, Jin C, Fu DL, Xu JF. World J Gastroenterol. 2020;26(22):3076-3086. doi: 10.3748/wjg.v26.i22.3076.

7.Blood-based Genomic Profiling of Circulating Tumor DNA from Patients with Advanced Pancreatic Cancer and its Value to Guide Clinical Treatment. Li H, Di Y, Li J, Jiang Y, He H, Yao L, Gu J, Lu J, Song J, Chen S, Cai S, Jin C, Yuan Z, Fu D. J Cancer. 2020;11(15):4316-4323. doi: 10.7150/jca.43087. eCollection 2020.

8.Controlling Nutritional Status score is superior to Prognostic Nutritional Index score in predicting survival and complications in pancreatic ductal adenocarcinoma: a Chinese propensity score matching study. Mao YS, Hao SJ, Zou CF, Xie ZB, Fu DL.Br J Nutr. 2020;124(11):1190-1197. doi: 10.1017/S0007114520002299. 

9.Partial pancreatic tail preserving subtotal pancreatectomy for pancreatic cancer: Improving glycemic control and quality of life without compromising oncological outcomes. You L, Yao L, Mao YS, Zou CF, Jin C, Fu DL. World J Gastrointest Surg. 2020;12(12):491-506. doi: 10.4240/wjgs.v12.i12.491.

10.Grading Solid Pseudopapillary Tumors of the Pancreas: the Fudan Prognostic Index. Yang F, Wu W, Wang X, Zhang Q, Bao Y, Zhou Z, Jin C, Ji Y, Windsor JA, Lou W, Fu D. Ann Surg Oncol. 2021;28(1):550-559. doi: 10.1245/s10434-020-08626-z. 

11.Basal microvilli define the metabolic capacity and lethal phenotype of pancreatic cancer.Han X, Ma L, Gu J, Wang D, Li J, Lou W, Saiyin H, Fu D. J Pathol. 2021 ;253(3):304-314. doi: 10.1002/path.5588. Epub 2021 Jan 22.

12.Prevalence and outcomes of acute pancreatitis in COVID-19: a meta-analysis. Yang F, Huang Y, Li T, Fu Y, Sun C, Xu Y, Windsor J, Fu D. Gut. 2021 :gutjnl-2021-325941. doi: 10.1136/gutjnl-2021-325941. 

13.Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment. Xie Z, Gao Y, Ho C, Li L, Jin C, Wang X, Zou C, Mao Y, Wang X, Li Q, Fu D, Zhang YF. Gut. 2021 :gutjnl-2020-323014. doi: 10.1136/gutjnl-2020-323014. 

14.Liver-Metastasis-Related Genes are Potential Biomarkers for Predicting the Clinical Outcomes of Patients with Pancreatic Adenocarcinoma. Dong Y, Tian J, Yan B, Lv K, Li J, Fu D. Pathol Oncol Res. 2021 ;27:1609822. doi: 10.3389/pore.2021.1609822. 

15.Prevalence and outcomes of acute pancreatitis in COVID-19: a meta-analysis. Yang F, Huang Y, Li T, Fu Y, Sun C, Xu Y, Windsor J, Fu D. Gut. 2022 Jul;71(7):1451-1453. doi: 10.1136/gutjnl-2021-325941. Epub 2021 Oct 20

16.Cancer-associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth. Yuan M, Tu B, Li H, Pang H, Zhang N, Fan M, Bai J, Wang W, Shu Z, DuFort CC, Huo S, Zhai J, Yao K, Wang L, Ying H, Zhu WG, Fu D, Hu Z, Zhao Y. Nat Cancer. 2022 Aug;3(8):945-960. doi: 10.1038/s43018-022-00426-6. Epub 2022 Aug 18.

17.The expression and survival significance of sodium glucose transporters in pancreatic cancer. Du J, Gu J, Deng J, Kong L, Guo Y, Jin C, Bao Y, Fu D, Li J.BMC Cancer. 2022 Jan 28;22(1):116. doi: 10.1186/s12885-021-09060-4.

18.The Intricate Crosstalk Between Insulin and Pancreatic Ductal Adenocarcinoma: A Review From Clinical to Molecular. Deng J, Guo Y, Du J, Gu J, Kong L, Tao B, Li J, Fu D.Front Cell Dev Biol. 2022 Feb 17;10:844028. doi: 10.3389/fcell.2022.844028. eCollection 2022.

19.Clinical significance of variant hepatic artery in pancreatic resection: A comprehensive review. Xu YC, Yang F, Fu DL.World J Gastroenterol. 2022 May 21;28(19):2057-2075. doi: 10.3748/wjg.v28.i19.2057.

20. Characterization of DNA damage response deficiency in pancreatic cancer patients from China.  Zhang X, Mao T, Zhang B, Xu H, Cui J, Jiao F, Chen D, Wang Y, Hu J, Xia Q, Li S, Yue M, Ma J, Yao J, Wang Y, Zhang X, Chen S, Bai Y, Wang Y, Zhang X, Liu Q, Sun Y, Fu D, Liu Y, Xiong L, Wang L.Cancer Commun (Lond). 2022 Jan;42(1):70-74. doi: 10.1002/cac2.12238. Epub 2021 Nov 24.

21. Identification of Genes Associated with Liver Metastasis in Pancreatic Cancer Reveals PCSK6 as a Crucial Mediator. He H, Zhang S, Yang H, Xu P, Kutschick I, Pfeffer S, Britzen-Laurent N, Grützmann R, Fu D, Pilarsky C.Cancers (Basel). 2022 Dec 30;15(1):241. doi: 10.3390/cancers15010241.

22.Prevalence and prognosis of increased pancreatic enzymes in patients with COVID-19: A systematic review and meta-analysis. Yang F, Xu Y, Dong Y, Huang Y, Fu Y, Li T, Sun C, Pandanaboyana S, Windsor JA, Fu D. Pancreatology. 2022 May;22(4):539-546. doi: 10.1016/j.pan.2022.03.014. Epub 2022 Mar 25.

23.The Role of Diabetes Mellitus in the Malignant Pancreatic Cyst Neoplasm Diagnosis and Prognosis. Deng J, Guo Y, Gu J, Du J, Kong L, Tao B, Li J, Fu D.Cancer Manag Res. 2022 Jun 22;14:2091-2104. doi: 10.2147/CMAR.S355365. eCollection 2022.

24.Gemcitabine-Loaded Albumin Nanoparticle Exerts An Antitumor Effect on Gemcitabine-Resistant Pancreatic Cancer Cells Induced by MDR1 and MRP1 Overexpression in Vitro. Kong L, Du J, Gu J, Deng J, Guo Y, Tao B, Jin C, Fu D, Li J.Front Surg. 2022 May 17;9:890412. doi: 10.3389/fsurg.2022.890412. eCollection 2022.