医学博士，第四军医大学唐都医院传染病科副主任医师。2005年毕业于第四军医大学获医学学士学位，2011年获第四军医大学传染病专业博士学位，博士毕业论文荣获陕西省优秀博士论文。曾于2009年至2010年在美国耶鲁大学病理学系进修，主攻乙型肝炎免疫发病机制的相关研究。主持国家自然科学基金两项，陕西省自然科学基金一项。第一/通讯作者发表SCI论文13篇，参与获得陕西省科技进步二等奖一项。长期在传染病医疗、教学和科研一线工作，主要从事病毒性肝炎、肝硬化、肾综合征出血热等常见传染病的诊治工作。

主要研究成果：

第一/通讯作者发表论文：

1.  Zhang Y, Cobleigh MA, Lian JQ, Huang CX, Booth CJ, Bai XF *, Robek MD *. A proinflammatory role for interleukin-22 in the immune response to hepatitis B virus. Gastroenterology. 2011, 141(5): 1897-1906.

2.  Peng MJ, Guo XQ, Zhang WL, Chen J, Kang W, Yang XF, Guo Y *, Zhang Y *. Effect of pegylated interferon-α2b add-on therapy on renal function in chronic hepatitis B patients: A real-world experience. Front Microbiol. 2022, 13: 980250. 

3.  Zhang Y, Kuang W, Li D, Li Y, Feng Y, Lyu X, Huang GB, Lian JQ, Yang XF, Hu C, Xie Y, Xue S, Tan J *. Natural Killer-Like B Cells Secreting Interleukin-18 Induces a Proinflammatory Response in Periodontitis. Front Immunol. 2021, 12: 641562.

4.  Zhang Y, Wang YY, Li XF, Ma CY, Li J, Kang W, Kang WZ, Wang LX, Huang CX, Sun YT, Lian JQ*. A human immunodeficiency virus-seronegative acquired immunodeficiency syndrome patient with opportunistic infections: A case report. Int J STD AIDS. 2022, 33(5): 515-518.

5.  Li H, Zhang T, Wang K, Lu M, Guo Y, Zhang Y *, Chen ZN *, Bian H *. MFGE8 protects against CCl4 -induced liver injury by reducing apoptosis and promoting proliferation of hepatocytes. J Cell Physiol. 2019, 234(9): 16463-16474.

6.  Dong J, Yang XF, Wang LX, Wei X, Wang AH, Hao CQ, Shen HJ, Huang CX, Zhang Y *, Lian JQ *. Modulation of Tim-3 expression by antigen-dependent and -independent factors on T cells from patients with chronic hepatitis B virus infection. Front Cell Infect Microbiol. 2017, 7: 98. 

7.   Zhang Y, Zhang WL, Pang XW, Wang LX, Wei X, Huang CX, Bai XF, Han S, Liu LN *, Lian JQ *. Effect of 48-week pegylated interferon α-2a or nucleos(t)ide analogue therapy on renal function in Chinese patients with chronic hepatitis B. Virol J. 2017, 14: 49.

8.  Wei X, Wang JP, Hao CQ, Yang XF, Wang LX, Huang CX, Bai XF, Lian JQ *, Zhang Y *. Notch signaling contributes to liver inflammation by regulation of interleukin-22-Producing cells in hepatitis B virus infection. Front Cell Infect Microbiol. 2016, 6: 132. 

9.  Lian JQ, Yang XF, Zhao RR, Zhao YY, Li Y, Zhang Y *, Huang CX *. Expression profiles of circulating cytokines, chemokines and immune cells in patients with hepatitis B virus infection. Hepat Mon. 2014, 14(6): e18892.

10.  Zhang Y, Su WJ, Wang J, Bai XF, Huang CX *, Lian JQ *. A fusion DNA vaccine encoding middle version of HBV envelope protein fused to interleukin-21 did not enhance HBV-specific immune response in mice. Viral Immunol. 2014, 27(9): 430-437.

11.  Zhang Y, Lian JQ, Li Y, Wang JP, Huang CX, Bai XF, Wang JP *. Telbivudine plus adefovir therapy for chronic hepatitis B patients with virological breakthrough or genotypic resistance to telbivudine. Eur J Gastroenterol Hepatol. 2013, 25(7): 814-819.

12. Zhang Y, Lian JQ, Huang CX, Wang JP, Wei X, Nan XP, Yu HT, Jiang LL, Wang XQ, Zhuang Y, Li XH, Li Y, Wang PZ, Robek MD, Bai XF *. Overexpression of Toll-like receptor 2/4 on monocytes modulates the activities of CD4(+)CD25(+) regulatory T cells in chronic hepatitis B virus infection. Virology. 2010, 397(1): 34-42.

13. Zhang Y, Li XH *, Jiang H, Huang CX, Wang PZ, Mou DL, Sun L, Xu Z, Wei X, Bai XF *. Expression of L protein of Hantaan virus 84FLi strain and its application for recovery of minigenomes. APMIS. 2008, 116(12): 1089-1096.