吴传新,重庆医科大学附属第二医院肝胆外科主任医师,硕士研究生导师,长期从事肝癌、肝硬化门静脉高压症、胰腺肿瘤、胆道疾病的外科手术治疗,擅长腹腔镜、微创外科手术,有丰富的临床经验和较深的造诣,对外科感染与信号转导和肝癌发生的分子机制有深入的研究。先后承担了国家自然科学基金、重庆市科委自然科学基金、重庆市教委科学技术研究项目、重庆市卫生局医学科研计划项目、重庆市卫生局中医药科技项目等多项科研项目。获重庆市卫生局医学科学技术成果一、二等奖。近年以第一作者和通讯作者发表SCI论文9篇,国内CSCD核心期刊发表论文40余篇。
主持或参加科研项目:
1.国家自然科学基金面上项目:miR-146b-5p通过NF-κB/GSDMD途径调控脓毒症免疫的实验研究,项目编号:81871608,2019.01-2022.12,57万元,参与,排名第一
2. 国家自然科学基金面上项目,81071339,HMGB1在HBV复制和乙肝肝损伤中的作用研究,2011/01-2013/12,35万元,已结题,主持
3. 重庆市科委自然科学基金计划资助项目,2010BB5378,HMGB1/RAGE在肝癌浸润转移发生机制中的作用,2010/10-2013/10,3万元,已结题,主持
4.重庆市卫生局医学科研计划项目,2010-2-130,ALR 在肝细胞癌中信号传导通路的研究,2010/07-2012/07,1.5万元,已结题,主持
5.重庆市卫生局中医药科技项目,2009-2-148,甘草甜素抑制脓毒症HMGB1释放的实验研究, 2010/01-2011/12,2万元,已结题,主持
6.重庆市教委科学技术研究项目,KJ060312,丙酮酸乙酯抑制内毒素介导Kupffer细胞高迁移率族蛋白1释放的分子机制研究, 2006/01-2007/12,2.5万元,已结题,主持
SCI论文
1. Jiahui He,Hang Sun,Fei Li,Hao Yang,Minggeng Lou,Shunde Wang,Chuanxin Wu.Efficacy and safety of raltitrexed‐based transcatheter arterial chemoembolization for intermediate and advanced hepatocellular carcinoma: A multicenter real‐world study. Hepatology Research, 2021;51:1153–1163(通讯作者)
2. JiaoJiao Wang,ChuanXin Wu,YunYing Wang,ChongXiang Chen, Jing Cheng, XiaoLong Rao,Hang Sun. The Role of HMGB1 in Invasive Candida albicans Infection. Mycopathologia, 2021 Dec;186(6):789-805(并列第一作者)
3. Chuan-Xin-Wu,Deng-Wang,Ying-Cai,Ao-Ran-Luo and Hang-Sun.Effect of Autologous Bone Marrow Stem Cell Therapy in Patients with Liver Cirrhosis: A Meta-analysis. Journal of Clinical and Translational Hepatology,2019,7:238-248
4.Wu CX#,Cheng J#,Wang YY,Wang JJ,Guo H,Sun H*,Microrna Expression Profiling of Macrophage Line RAW264.7 Infected By Candida Albicans,Shock,2017,47(4):520-530
5. Wu CX#, Cheng J#, Wang YY, Wang JJ, Guo H, Sun H*, Microrna Expression Profiling of Macrophage Line RAW264.7 Infected By Candida Albicans,Shock,2017,47(4):520-530
6. Wu CX#,He LX#,Guo H,Tian XX,Liu Q,Sun H*,Inhibition effect of glycyrrhizin in lipopolysaccharide-induced high-mobility group box1 releasing and expression from RAW264.7 cells,Shock,2015,43(4):412-421
7. Akanand Singh1,Yi Feng,Nisha Mahato,Jinzheng Li,Chuanxin Wu,Jianping Gong,Role of high-mobility group box 1 in patients with acute obstructive suppurative cholangitis-induced sepsis,Journal of Inflammation Research,2015,8:71–77(通讯作者)
8. Wu CX,Guo H,Gong JP,Liu Q,Sun H*,The role of high mobility group box chromosomal protein 1 expression in the differential diagnosis of hepatic actinomycosis:a case report,Journal of Medical Case Reports,2013,7(31):1-7
9. Wu CX,Sun H*,Wang HL,Chi JM,Liu Q,Guo H,Gong JP,Evaluation of high mobility group box 1 protein as a presurgical diagnostic marker reflecting the severity of acute appendicitisas a presurgical diagnostic marker reflecting the severity of acute appendicitis, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2012,20(1):61
10. Wu CX#,Sun H#,Liu Q,Guo H, Gong JP*,LPS Induces HMGB1 Relocation and Release by Activating the NF-KB-CBP Signal Transduction Pathway in the Murine Macrophage-Like Cell Line RAW264.7,J Surg Res,2012,175(3): 88-100
获得学术奖励
1. 吴传新(1/9),腹腔镜胆囊切除术胆管损伤的诊断、治疗和预防措施,重庆市卫生局,医学科技成果奖,二等奖,2013
(吴传新,李起,龚建平,陈应果,李培志,张建红,王小梅,秦德芳,刘维会)
2. 吴传新(1/1),内毒素介导Kupffer细胞激活的跨膜信号传导分子机制研究,重庆市卫生局,医学科学技术成果奖,一等奖,2003-2004