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原发性硬化性胆管炎药物治疗进展
DOI: 10.12449/JCH240526
利益冲突声明：本文不存在任何利益冲突。
作者贡献声明：盛夏负责文献检索，撰写论文；纪庆明负责资料分析；李昕宇、王丽宏、牛俊奇负责指导及最终定稿。
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摘要: 原发性硬化性胆管炎（PSC）是一种以慢性进行性胆管炎症为特征的胆汁淤积性疾病，在我国发病率低，预后差，尚无药物治疗能改变PSC的进程，肝移植是唯一有效治疗手段，移植后5年生存率可达85％。基于PSC现状，药物治疗面临巨大挑战。目前治疗PSC的药物尚处于临床试验阶段，初步显示出应用前景，其中熊去氧胆酸是研究最广泛、最常用的药物。除此之外，还有很多新兴药物正在研究中。本文将围绕PSC最新药物治疗进展进行概述。Abstract: Primary sclerosing cholangitis （PSC） is a cholestatic disease characterized by chronic progressive bile duct inflammation and has a low incidence rate and poor prognosis in China. There is still no drug therapy that can change the course of PSC， and liver transplantation is the only effective treatment for PSC， with a 5-year survival rate of 85% after transplantation. Drug therapy for PSC is facing great challenges based on the current status of PSC. At present， drugs for the treatment of PSC are in the stage of clinical trials and have shown certain application prospect， among which ursodeoxycholic acid is the most widely studied and commonly used drug. In addition， there are many emerging drugs in the pipeline. This article summarizes the latest advances in drug therapy for PSC.
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Key words:
- Cholangitis， Sclerosing /
- Ursodeoxycholic Acid /
- Obecholic Acid /
- Drug Therapy
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