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慢性肝病合并2型糖尿病的rs2943650位点变异及胰岛素抵抗之间的关系

窦爱华 惠威 刘梅 魏琳琳 赵娟 马春华 郑小勤 熊芳 杨雪 张美 徐斌

窦爱华, 惠威, 刘梅, 魏琳琳, 赵娟, 马春华, 郑小勤, 熊芳, 杨雪, 张美, 徐斌. 慢性肝病合并2型糖尿病的rs2943650位点变异及胰岛素抵抗之间的关系[J]. 临床肝胆病杂志, 2018, 34(11): 2379-2382. DOI: 10.3969/j.issn.1001-5256.2018.11.022.
引用本文: 窦爱华, 惠威, 刘梅, 魏琳琳, 赵娟, 马春华, 郑小勤, 熊芳, 杨雪, 张美, 徐斌. 慢性肝病合并2型糖尿病的rs2943650位点变异及胰岛素抵抗之间的关系[J]. 临床肝胆病杂志, 2018, 34(11): 2379-2382. DOI: 10.3969/j.issn.1001-5256.2018.11.022.
Dou AiHua, Hui Wei, Liu Mei, Wei LinLin, Zhao Juan, Ma ChunHua, Zheng XiaoQin, Xiong Fang, Yang Xue, Zhang Mei, Xu Bin. Association between rs2943650 mutation and insulin resistance in patients with chronic liver disease and type 2 diabetes mellitus[J]. J Clin Hepatol, 2018, 34(11): 2379-2382. DOI: 10.3969/j.issn.1001-5256.2018.11.022.
Citation: Dou AiHua, Hui Wei, Liu Mei, Wei LinLin, Zhao Juan, Ma ChunHua, Zheng XiaoQin, Xiong Fang, Yang Xue, Zhang Mei, Xu Bin. Association between rs2943650 mutation and insulin resistance in patients with chronic liver disease and type 2 diabetes mellitus[J]. J Clin Hepatol, 2018, 34(11): 2379-2382. DOI: 10.3969/j.issn.1001-5256.2018.11.022.

慢性肝病合并2型糖尿病的rs2943650位点变异及胰岛素抵抗之间的关系

DOI: 10.3969/j.issn.1001-5256.2018.11.022
基金项目: 

北京卫生系统高技术人才培养项目基金(2015-3-104); 北京市教委科技计划面上项目(KM201610025021); 北京市医院管理局临床医学发展专项(XMLX201830); 

详细信息
  • 中图分类号: R587.1;R575

Association between rs2943650 mutation and insulin resistance in patients with chronic liver disease and type 2 diabetes mellitus

Research funding: 

 

  • 摘要:

    目的探讨肝病合并糖尿病患者中胰岛素抵抗的特点,并寻找导致胰岛素抵抗的可能途径。方法选取2017年9月-2018年3月北京佑安医院收治的肝病合并2型糖尿病患者67例,分析在慢性肝炎及肝硬化阶段胰岛B细胞分泌功能和胰岛素抵抗情况,并检测rs2943650位点是否变异,分析该位点变异与不同程度肝损伤的胰岛素抵抗的关系。计量资料组间比较采用t检验或Kruskal Wallis H秩和检验,计数资料组间比较采用χ2检验。结果慢性肝炎合并2型糖尿病患者胰岛B细胞的分泌功能与肝硬化合并2型糖尿病患者比较差异无统计学意义(52. 72±34. 56 vs 52. 35±36. 59,t=0. 24,P=0. 99),胰岛素抵抗指数在二者间差异具有统计学意义(1. 33±0. 62 vs 2. 08±1. 79,t=2. 27,P=0. 02)。rs2943650位点变异组胰岛素抵抗与未变异组比较差异有统计学意义(t=2. 11,P=0. 04); rs2943650变异和未变异在肝脏疾病的不同阶段存在明显差异(χ2=6. 73,P=0. 01),rs2943...

     

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  • 期刊类型引用(4)

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    2. 吴小娟,黄家明,谢宁生,李玉平. 胰岛素抵抗对不同慢性肝病患者代谢紊乱的影响. 中国现代医生. 2023(27): 45-48 . 百度学术
    3. 徐丽英,方豫东,曹烨民,赵满忱,周敏杰. 血清脂联素、胱抑素C与糖尿病肢体动脉闭塞症的糖脂代谢的关系. 中国医药导报. 2020(01): 98-101 . 百度学术
    4. 李青,曾安平,江燕,陈继红,王旭方. 余承惠教授从湿论治慢性肾脏病经验. 中国医药导报. 2019(30): 151-154 . 百度学术

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