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熊去氧胆酸联合甘草酸二铵治疗原发性胆汁性胆管炎的效果观察

张玉果 赵素贤 李文聪 任伟光 南月敏

王甸北, 赵礼金, 涂奎, 余琴. 解剖性肝切除术治疗肝内胆管结石的效果观察[J]. 临床肝胆病杂志, 2017, 33(1): 102-105. DOI: 10.3969/j.issn.1001-5256.2017.01.022.
引用本文: 王甸北, 赵礼金, 涂奎, 余琴. 解剖性肝切除术治疗肝内胆管结石的效果观察[J]. 临床肝胆病杂志, 2017, 33(1): 102-105. DOI: 10.3969/j.issn.1001-5256.2017.01.022.
Wang DianBei, Zhao LiJin, Tu Kui, Yu Qin. Clinical effect of anatomical hepatectomy in treatment of intrahepatic bile duct stones[J]. J Clin Hepatol, 2017, 33(1): 102-105. DOI: 10.3969/j.issn.1001-5256.2017.01.022.
Citation: Wang DianBei, Zhao LiJin, Tu Kui, Yu Qin. Clinical effect of anatomical hepatectomy in treatment of intrahepatic bile duct stones[J]. J Clin Hepatol, 2017, 33(1): 102-105. DOI: 10.3969/j.issn.1001-5256.2017.01.022.

熊去氧胆酸联合甘草酸二铵治疗原发性胆汁性胆管炎的效果观察

DOI: 10.3969/j.issn.1001-5256.2019.06.028
基金项目: 

中国肝炎防治基金会-天晴肝病研究基金(TQGB20140203); 河北省中医药管理局课题(2014143); 

详细信息
  • 中图分类号: R575.7

Clinical effect of ursodeoxycholic acid combined with diammonium glycyrrhizinate in treatment of primary biliary cholangitis

Research funding: 

 

  • 摘要:

    目的对比熊去氧胆酸(UDCA)联合甘草酸二铵与单用UDCA治疗原发性胆汁性胆管炎(PBC)的生化学应答和肝脏硬度变化情况。方法选取2014年1月-2016年3月就诊于河北医科大学第三医院中西医结合肝病科的PBC患者66例,均行FibroTouch检测,以肝脏硬度值表示肝纤维化程度,对比分析UDCA联合甘草酸二铵与单用UDCA治疗PBC患者4、12、24和48周的肝生化学应答和治疗24、48周后肝脏硬度值变化情况。两组间计量资料比较采用两独立样本t检验,治疗前后生化学指标及肝脏硬度值比较采用配对t检验。结果 UDCA联合甘草酸二铵治疗组与单用UDCA对照组比较,联合治疗组AST水平在治疗后4周[(38. 4±15. 4) U/L vs (61. 6±28. 8) U/L,t=2. 684,P=0. 012]、12周[(36. 4±12. 6) U/L vs (58. 1±24. 8) U/L,t=2. 953,P=0. 006)]、24周[(37. 0±8. 5) U/L vs (52. 9±17. 2) U/L,t=3. 134,P=0. 004]、48周[(34. 9±7. 9) U...

     

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  • 收稿日期:  2019-02-14
  • 出版日期:  2019-06-20
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