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陕西地区孕妇HBV感染现状与母婴传播的危险因素

余强 王静 刘锦锋 闫涛涛 冯亚丽 何英利 代晓敏 陈天艳 赵英仁 朱娅鸽

安梓铭, 冯琴. 磁共振质子密度脂肪分数——一种具有潜力的非酒精性脂肪性肝炎临床试验替代终点[J]. 临床肝胆病杂志, 2021, 37(6): 1445-1448. DOI: 10.3969/j.issn.1001-5256.2021.06.047.
引用本文: 安梓铭, 冯琴. 磁共振质子密度脂肪分数——一种具有潜力的非酒精性脂肪性肝炎临床试验替代终点[J]. 临床肝胆病杂志, 2021, 37(6): 1445-1448. DOI: 10.3969/j.issn.1001-5256.2021.06.047.
AN ZM, FENG Q. Magnetic resonance imaging-proton density fat fraction: A potential surrogate endpoint for nonalcoholic steatohepatitis clinical trials [J]. J Clin Hepatol, 2021, 37(6): 1445-1448. DOI: 10.3969/j.issn.1001-5256.2021.06.047.
Citation: AN ZM, FENG Q. Magnetic resonance imaging-proton density fat fraction: A potential surrogate endpoint for nonalcoholic steatohepatitis clinical trials [J]. J Clin Hepatol, 2021, 37(6): 1445-1448. DOI: 10.3969/j.issn.1001-5256.2021.06.047.

陕西地区孕妇HBV感染现状与母婴传播的危险因素

DOI: 10.3969/j.issn.1001-5256.2019.07.013
基金项目: 

国家自然科学基金资助项目(81670537); 西安交通大学第一附属医院院基金资助项目(YK201511); 

详细信息
  • 中图分类号: R714.251

Current status of hepatitis B virus infection among pregnant women in Shaanxi Province, China and risk factors for mother-to-infant transmission

Research funding: 

 

  • 摘要: 目的调查陕西省孕妇HBV感染率并筛选母婴传播高危人群。方法自2010年-2015年连续调查了陕西省18家医院13 451名孕妇HBV感染情况,对所有HBs Ag阳性孕妇所生婴儿进行联合免疫,采用单因素及多因素logistic回归分析母婴传播的高危因素。计量资料组间比较采用t检验或Mann-Whitney U检验。计数资料多组间比较采用χ2检验。结果陕西省孕妇HBsAg流行率为7. 07%,陕南地区高达9. 40%。HBV母婴传播率为5. 21%,单因素分析显示母亲HBsAg滴度、HBeAg滴度、HBeAg阳性及HBV DNA载量与婴儿HBV感染相关,多因素分析显示母亲HBV DNA载量是母婴传播的独立危险因素(相对危险度:1. 586,95%可信区间:1. 020~2. 465,P=0. 041)。发生母婴传播的HBV感染孕妇中,84. 62%为HBeAg阳性且HBV DNA> 106IU/ml;发生母婴传播的婴儿15. 38%来自于HBeAg阴性的HBV感染孕妇。HBeAg阳性且HBV DNA> 106IU/ml的孕妇中,婴儿发生母婴传播的相对危险度...

     

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  • 收稿日期:  2019-02-02
  • 出版日期:  2019-07-20
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