omega-3多不饱和脂肪酸治疗非酒精性脂肪性肝病的研究进展

郭悦承; 陆伦根

doi:10.3969/j.issn.1001-5256.2020.01.047

omega-3多不饱和脂肪酸治疗非酒精性脂肪性肝病的研究进展

DOI: 10.3969/j.issn.1001-5256.2020.01.047

上海交通大学附属第一人民医院消化科

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中图分类号: R575.5
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出版历程
- 收稿日期: 2019-08-09
- 出版日期: 2020-01-20

Research advances in omega-3 polyunsaturated fatty acids in treatment of nonalcoholic fatty liver disease

Department of Gastroenterology,Shanghai General Hospital

摘要

摘要: 随着人们生活方式和饮食结构的改变,非酒精性脂肪性肝病（NAFLD）发病率逐年上升,严重威胁人类健康。NAFLD疗法一直是基础和临床肝病研究的热门领域。近年来,诸多研究揭示omega-3多不饱和脂肪酸（ω3-PUFA）可促进脂肪酸氧化并改善肠道稳态,从而改善脂代谢和肝脏炎症,因而越来越多的临床研究开始将ω3-PUFA运用于NAFLD的治疗中。然而,ω3-PUFA治疗NAFLD的机制尚不明确,相关临床研究也存在一定局限性。主要介绍了ω3-PUFA在NAFLD中发挥的作用以及相关的临床研究结果,并进一步讨论ω3-PUFA治疗NAFLD尚需解决的问题。
- 非酒精性脂肪性肝病 /
- 脂肪酸类,ω3 /
- 治疗学
Abstract: With the changes in people's lifestyle and dietary structure,the incidence rate of nonalcoholic fatty liver disease(NAFLD) has been increasing year by year,and NAFLD has become a serious threat to human health. The treatment of NAFLD has always been a hot topic of basic and clinical research on liver diseases. In recent years,many studies have revealed that omega-3 polyunsaturated fatty acids(ω3-PUFA) can promote fatty acid oxidation,improve intestinal homeostasis,and thus improve lipid metabolism and liver inflammation,and therefore,more and more clinical studies have applied ω3-PUFA in the treatment of NAFLD. However,the mechanism of ω3-PUFA in the treatment of NAFLD is still unclear,and there are certain limitations in related clinical studies. This article mainly introduces the role of ω3-PUFA in NAFLD and the results of related clinical studies and further discusses the problems that need to be solved in ω3-PUFA for the treatment of NAFLD.
- non-alcoholic fatty liver disease /
- fatty acids,omega-3 /
- therapeutics

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参考文献(32)

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