肝衰竭患者的出凝血状态评估策略

吕滨月; 李谦

doi:10.3969/j.issn.1001-5256.2020.04.049

肝衰竭患者的出凝血状态评估策略

DOI: 10.3969/j.issn.1001-5256.2020.04.049

吕滨月,
李谦

天津医科大学天津市第二人民医院ICU

基金项目:

国家科技重大专项课题(2018ZX10725506-002)；

详细信息

中图分类号: R575.3
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出版历程
- 出版日期: 2020-04-20

Strategies in the evaluation of coagulation status in patients with liver failure

Lyu BinYue,
Li Qian

ICU, Tianjin Second People’s Hospital, Tianjin Medical University

Research funding:

摘要

摘要: 肝衰竭患者体内存在复杂的凝血功能异常,目前尚无完整的评价体系对患者的出血及血栓风险进行评估。总结了传统的常规凝血试验和近年来出凝血评估的热点技术黏弹性试验与凝血酶生成分析在肝衰竭患者中的应用。分析表明仅用单一的方法对肝衰竭患者出凝血风险进行评估准确性差,进一步探索更为准确有效的评估方法应综合考虑肝衰竭时患者凝血与抗凝因素、纤溶系统、血小板功能及全身状态等多方面因素并结合新兴的凝血过程测定技术。
- 肝功能衰竭 /
- 出血 /
- 凝血
Abstract: Complex coagulation disorders are observed in patients with liver failure,and currently there is no comprehensive evaluation system to assess the risk of bleeding and thrombosis in such patients. This article summarizes the application of routine coagulation test and the hot techniques for coagulation assessment such as viscoelasticity test and thrombin generation analysis in patients with liver failure. The analysis shows that a single method has poor accuracy in evaluating the risk of bleeding and thrombosis and further exploration of a more accurate and effective assessment method should comprehensively consider the factors such as coagulation and anticoagulation factors,fibrinolytic system,platelet function,and systemic status of patients with liver failure,with reference to emerging coagulation process measurement techniques.
- liver failure /
- hemorrhage /
- coagulation

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参考文献(32)

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