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HCV感染者直接抗病毒药物治疗前后CD8+T淋巴细胞衰老和功能相关指标的变化

张沛欣 边培育 叶传涛 郑煦暘 范超 张颖 贾战生 周云

张沛欣, 边培育, 叶传涛, 郑煦暘, 范超, 张颖, 贾战生, 周云. HCV感染者直接抗病毒药物治疗前后CD8+T淋巴细胞衰老和功能相关指标的变化[J]. 临床肝胆病杂志, 2020, 36(7): 1496-1501. DOI: 10.3969/j.issn.1001-5256.2020.07.011.
引用本文: 张沛欣, 边培育, 叶传涛, 郑煦暘, 范超, 张颖, 贾战生, 周云. HCV感染者直接抗病毒药物治疗前后CD8+T淋巴细胞衰老和功能相关指标的变化[J]. 临床肝胆病杂志, 2020, 36(7): 1496-1501. DOI: 10.3969/j.issn.1001-5256.2020.07.011.
Zhang PeiXin, Bian PeiYu, Ye ChuanTao, Zheng XuYang, Fan Chao, Zhang Ying, Jia ZhanSheng, Zhou Yun. Changes in senescence-and function-related parameters of CD8+T cells after direct-acting antiviral treatment in patients with hepatitis C virus infection[J]. J Clin Hepatol, 2020, 36(7): 1496-1501. DOI: 10.3969/j.issn.1001-5256.2020.07.011.
Citation: Zhang PeiXin, Bian PeiYu, Ye ChuanTao, Zheng XuYang, Fan Chao, Zhang Ying, Jia ZhanSheng, Zhou Yun. Changes in senescence-and function-related parameters of CD8+T cells after direct-acting antiviral treatment in patients with hepatitis C virus infection[J]. J Clin Hepatol, 2020, 36(7): 1496-1501. DOI: 10.3969/j.issn.1001-5256.2020.07.011.

HCV感染者直接抗病毒药物治疗前后CD8+T淋巴细胞衰老和功能相关指标的变化

DOI: 10.3969/j.issn.1001-5256.2020.07.011
基金项目: 

国家自然科学基金项目(81601749); 

详细信息
  • 中图分类号: R512.63

Changes in senescence-and function-related parameters of CD8+T cells after direct-acting antiviral treatment in patients with hepatitis C virus infection

Research funding: 

 

  • 摘要:

    目的观察HCV感染者DAA治疗前后CD8+T淋巴细胞衰老、功能相关指标变化,并探讨其临床意义。方法选取2017年1月-2018年12月于空军军医大学第二附属医院就诊的HCV感染者26例,患者接受索磷布韦联合达卡他韦片治疗。并纳入治愈者22例,健康对照者20例。采用流式细胞仪检测CD8+T淋巴细胞上SIRT1、CD57、PD-1、Tim-3等相关分子表达,并采用RT-PCR方法检测p21、p53表达水平,Luminex液相悬浮芯片检测样本外周血衰老相关分泌表型。计量资料多组间比较采用单因素方差分析,进一步两两比较采用LSD-t检验。结果 SIRT1、PD-1、Tim-3在3组间表达差异均有统计学意义(F值分别为6. 712、4. 202、4. 575,P值均<0. 05)。与健康对照组相比,HCV组CD8+T细胞上SIRT1、PD-1、Tim-3表达水平明显上升(P值均<0. 05),HCV治愈组Tim-3表达水平明显上升(P <0.>0. 05)。p53、p21在3组间表达差异有统计学意义(F...

     

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  • 期刊类型引用(4)

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    2. 黄辉,徐列明,平键,周扬. 扶正化瘀方通过改变急性肝损伤小鼠模型肝脏CD8~+T淋巴细胞表型功能预防肝纤维化的价值分析. 临床肝胆病杂志. 2022(02): 342-346 . 本站查看
    3. 李瑞娟,权会琴,王晓艳,边培育,叶传涛,范超,张颖,周云. HCV感染者直接抗病毒药物治疗对miR-181a调节CD4~+T淋巴细胞衰老相关指标的影响. 空军军医大学学报. 2022(09): 995-1000 . 百度学术
    4. 廖宝林,李凌华,钟活麟,李虹,李永红,陈少贞,温春燕,胡凤玉,兰芸,蔡卫平. 直接抗病毒药物治疗HIV/HCV合并感染患者长期疗效及肝纤维化改变. 中华肝脏病杂志. 2021(08): 776-780 . 百度学术

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  • 出版日期:  2020-07-20
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