Kupffer细胞在肝细胞癌中的调控机制

熊平福; 陈浩; 付文广; 谭鹏; 程永浪; 黎靖

doi:10.3969/j.issn.1001-5256.2021.10.040

Kupffer细胞在肝细胞癌中的调控机制

DOI: 10.3969/j.issn.1001-5256.2021.10.040

熊平福^a,
陈浩^a,
付文广^a,
谭鹏^b,
程永浪^a,
黎靖^a, ,

a.
西南医科大学附属医院肝胆外科, 四川泸州 646000
b.
西南医科大学附属医院四川省院士(专家工作站), 四川泸州 646000

基金项目:

湖北陈孝平科技发展基金会 (CXPJJH11900001-2019339);

西南医科大学科技战略合作应用基础研究项目 (2018LZXNYD-ZK14)

详细信息

通信作者:
黎靖，1206958961@qq.com

中图分类号: R735.7
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- 被引次数: 0
出版历程
- 收稿日期: 2021-03-08
- 录用日期: 2021-05-08
- 出版日期: 2021-10-20

Research advances in Kupffer cells participating in the regulation of hepatocellular carcinoma

a.
Department of Hepatobiliary Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China
b.
Academician (Expert) Workstation of Sichuan Province, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China

Research funding:

Chen Xiao-Ping for the Development of Science and Technology of Hubei Province (CXPJJH11900001-2019339);

Southwest Medical University Science and Technology Strategic Cooperation Applied Basic Research Project (2018LZXNYD-ZK14)

摘要

摘要: 肝细胞癌(HCC)是一种在全球范围内常见的高死亡率原发性肝癌。HCC在我国常见恶性肿瘤中发病率排第四位，死亡率排第二位，严重威胁着国民的健康和生命安全。主要介绍了Kupffer细胞在HCC中的双重作用，简述了其与肝实质细胞和非实质细胞的交互作用及其针对性靶点的治疗。分析表明深入研究Kupffer细胞对HCC的调控有助于为HCC的进一步治疗提供新的思路。
- 癌, 肝细胞 /
- 枯否细胞 /
- 细胞因子类
Abstract: Hepatocellular carcinoma (HCC) is a common type of primary liver cancer with high mortality worldwide. Among the common malignant tumors in China, HCC ranks fourth in terms of incidence rate and ranks second in terms of mortality, which seriously threatens the health and life safety of the Chinese people. This article mainly introduces the dual role of Kupffer cells (KCs) in HCC and briefly describes its interaction with liver parenchymal cells and nonparenchymal cells and related targeted treatment methods. The analysis shows that in-depth research on KCs in the regulation of HCC helps to provide new ideas for further treatment of HCC.
- Carcinoma, Hepatocellular /
- Kupffer Cells /
- Cytokines

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图 1 Kupffer细胞的调控机制

注: “+”，代表促进; “-”，代表抑制。

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