钠牛磺胆酸共转运多肽在肝胆疾病中的研究进展

高小强; 左石; 贾晓东; 陆荫英

doi:10.3969/j.issn.1001-5256.2022.05.043

钠牛磺胆酸共转运多肽在肝胆疾病中的研究进展

DOI: 10.3969/j.issn.1001-5256.2022.05.043

高小强^{1, 2},
左石¹,
贾晓东²,
陆荫英^2, , ,

1.
贵州医科大学附属医院肝胆外科，贵阳 550004
2.
中国人民解放军总医院第五医学中心肝脏肿瘤诊疗与研究中心，北京 100039

基金项目:

北京市自然科学基金面上项目 (7212099);

深圳市科技创新委员会可持续发展专项 (2019N002);

国家自然科学基金 (81902495);

解放军总医院扶持项目 (QNF19040)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：高小强负责资料分析，撰写论文; 左石、贾晓东负责提出具体修改意见并进行修改; 陆荫英负责拟定撰写思路，指导文章写作并最终定稿。

详细信息

通信作者:
陆荫英，luyinying1973@163.com

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出版历程
- 收稿日期: 2021-09-07
- 录用日期: 2021-10-25
- 出版日期: 2022-05-20

Research advances in sodium taurocholate cotransporting polypeptide in hepatobiliary diseases

Xiaoqiang GAO^{1, 2},
Shi ZUO¹,
Xiaodong JIA²,
Yinying LU^{2
, ,
,}

1.
Department of Hepatobiliary Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China
2.
Comprehensive Liver Cancer Center, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China

Research funding:

General Projects of Beijing Natural Science Foundation (7212099);

Special Sustainable Development Project of Shenzhen Science and Technology Innovation Committee (2019N002);

National Natural Science Foundation of China (81902495);

Support Project of PLA General Hospital (QNF19040)

More Information

Corresponding author: LU Yinying, luyinying1973@163.com(ORCID: 0000-0002-7737-2334)

摘要

摘要: 钠牛磺胆酸共转运多肽(NTCP)既是胆汁酸吸收入肝的重要转运体，又是HBV、HDV的功能性受体; 其结构、功能、基因特点、表达调控机制等已得到广泛研究; 且NTCP与慢性病毒性肝炎、非酒精性脂肪性肝病、肝纤维化、原发性胆汁性胆管炎、肝细胞癌相关，本文系统阐述了NTCP在各种肝胆疾病中的作用，为相关疾病的诊断及治疗提供新方向。
- 肝炎, 病毒性, 人 /
- 非酒精性脂肪性肝病 /
- 肝硬化 /
- 肝硬化, 胆汁性 /
- 癌, 肝细胞 /
- 钠牛磺胆酸共转运多肽
Abstract: Sodium taurocholate cotransporting polypeptide (NTCP) is not only an important transporter for bile acid absorption into the liver, but also a functional receptor for HBV and HDV, and extensive studies have been performed for its structure, function, gene characteristics, and expression and regulation mechanisms. NTCP is also associated with chronic viral hepatitis, nonalcoholic fatty liver disease, liver fibrosis, primary biliary cholangitis, and hepatocellular carcinoma. This article elaborates on the role of NTCP in various hepatobiliary diseases, so as to provide new direction for the diagnosis and treatment of related diseases.
- Hepatitis, Viral, Human /
- Non-alcoholic Fatty Liver Disease /
- Liver Cirrhosis /
- Liver Cirrhosis, Biliary /
- Carcinoma, Hepatocellular /
- Sodium Taurocholate Co-transporting Polypeptide

HTML全文

图 1 胆汁酸盐调控NTCP表达的机制

注：(+)，促进; (-)，抑制。

Figure 1. Mechanism of bile salts regulating NTCP expression

下载: 全尺寸图片幻灯片

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