2016 No. 9

Cover Content

Previous Issue | Next Issue

Select articles

Display Method:

Editorial

A new understanding of etiological treatment in patients with severe viral hepatitis

Wang YuMing

2016, 32(9): 1637-1643. DOI: 10.3969/j.issn.1001-5256.2016.09.002

Abstract(2115)

PDF (1533KB)(550)

Abstract:

Severe viral hepatitis has a various etiology,which varies greatly among different regions. Hepatitis B and hepatitis C are commonly seen in China. It has been proved that antiviral therapy has great significance in HBV- related severe liver disease,and they often need long- term or lifetime medicat...

Therapeutic guidelines

Updated key points and clinical pathway for NCCN clinical practice guidelines in oncology: hepatobiliary cancers(Version2.2016)

Zhu Peng, Wang YuMing

2016, 32(9): 1644-1652. DOI: 10.3969/j.issn.1001-5256.2016.09.003

Abstract(2340)

PDF (898KB)(544)

Abstract:

An excerpt of KASL clinical practice guidelines: management of chronic hepatitis B (2016)

Li Juan, Xu BaiGuo, Han Tao

2016, 32(9): 1653-1658. DOI: 10.3969/j.issn.1001-5256.2016.09.004

Abstract(2157)

PDF (1516KB)(456)

Abstract:

An excerpt of the Japanese Society of Gastroenterology of evidence-based clinical practice guidelines for liver cirrhosis(2015)

Zhang Hong, Han Jing, Zhang XiaoLan

2016, 32(9): 1659-1663. DOI: 10.3969/j.issn.1001-5256.2016.09.005

Abstract(2323)

PDF (1778KB)(535)

Abstract:

National Cancer Centre Singapore consensus guidelines for hepatocellular carcinoma(2016)

Zhang Hao, Tian She, Jiang JianXin

2016, 32(9): 1664-1667. DOI: 10.3969/j.issn.1001-5256.2016.09.006

Abstract(2370)

PDF (2064KB)(462)

Abstract:

Discussions by experts

Current status of liver failure treatment

Ma Zhen, Wu Yun

2016, 32(9): 1668-1672. DOI: 10.3969/j.issn.1001-5256.2016.09.007

Abstract(2469)

PDF (1510KB)(546)

Abstract:

Liver failure is severe liver injury caused by various factors. This article summarizes currently used therapeutic methods for liver failure,and the universally acknowledged therapeutic methods include intensive care and supportive care,etiological treatment,regulation of immune function,prevention ...

Disease assessment and prognosis of liver failure

Zhang Jing, Zhou XinMin

2016, 32(9): 1673-1677. DOI: 10.3969/j.issn.1001-5256.2016.09.008

Abstract(2574)

PDF (1514KB)(479)

Abstract:
Liver failure has a high fatality rate and greatly threatens human health. Liver transplantation can effectively reduce the fatality rate. However,the problems such as donor shortage and allograft rejection limit the wide application of liver transplantation. An accurate early assessment helps to ev...

Research advances in clinical diagnosis,prognostic evaluation,and treatment of liver failure

Lin Feng

2016, 32(9): 1678-1683. DOI: 10.3969/j.issn.1001-5256.2016.09.009

Abstract(423)

PDF (245KB)(527)

Abstract:
Liver failure usually has rapid progression and poor prognosis and is one of the major causes of death in patients with severe hepatitis. This article describes the clinical diagnosis,prognostic evaluation,and therapeutic methods of liver failure and points out that the different opinions on the dia...

Definition,pathophysiology,and clinical management of acute-on-chronic liver failure

Liu HaiXia, Zhu YueKe, Meng QingHua

2016, 32(9): 1684-1687. DOI: 10.3969/j.issn.1001-5256.2016.09.010

Abstract(2854)

PDF (1500KB)(520)

Abstract:
Acute- on- chronic liver failure( ACLF) is defined as rapid deterioration of liver function under acute attack in patients with chronic liver disease and is associated with an extremely high mortality. Since the basis of liver disease and potential pathogenic factors for acute injury are different i...

Advances in diagnosis and treatment of patients with acute-on-chronic liver failure complicated by acute kidney injury

Li XiaoPeng, Wu ZhenPing, Zhang LunLi, Li Ming

2016, 32(9): 1688-1693. DOI: 10.3969/j.issn.1001-5256.2016.09.011

Abstract(2647)

PDF (1535KB)(570)

Abstract:
Acute- on- chronic liver failure( ACLF) is the most common type of liver failure in China,and it has complicated clinical manifestations and high mortality. When the patients experience ACLF complicated by acute kidney injury( AKI),they tend to have a prolonged length of hospital stay and a high ris...

Diagnosis and treatment of invasive fungal diseases in patients with severe liver diseases

Zang Hong, Xin ShaoJie

2016, 32(9): 1694-1698. DOI: 10.3969/j.issn.1001-5256.2016.09.012

Abstract(2474)

PDF (1519KB)(521)

Abstract:

Invasive fungal diseases( IFDs) are an important factor affecting the prognosis of patients with severe liver diseases,and their early diagnosis remains a challenge for clinicians. The four most commonly seen IFDs are candidiasis,aspergillosis,cryptococcosis,and pneumocystis pneumonia. We should pay...

Mechanism of action of direct-acting antiviral agents in treatment of chronic hepatitis C

Wen XiaoYu, Niu JunQi

2016, 32(9): 1699-1705. DOI: 10.3969/j.issn.1001-5256.2016.09.013

Abstract(3185)

PDF (1827KB)(630)

Abstract:
With the development and launch of direct- acting antiviral agents( DAAs) in the world in recent years,therapeutic regimens for chronic hepatitis C are constantly evolving. DAAs will also be launched in China in the near future. DAAs mainly target at the non-structural proteins of HCV and can inhibi...

Advances in Roussel Uclaf Causality Assessment Method for diagnosis of drug-induced liver injury and its comparison with structured expert opinion process

Yu YueCheng, Fan Ye

2016, 32(9): 1706-1713. DOI: 10.3969/j.issn.1001-5256.2016.09.014

Abstract(3298)

PDF (1626KB)(512)

Abstract:
Up to now,the diagnosis of drug- induced liver injury( DILI) still relies on the exclusive method,and the Roussel Uclaf Causality Assessment Method( RUCAM) is the most commonly used scale. Since the release of the first version of RUCAM scale in 1993,the second version was released in 2015,in which ...

Original articles_Viral hepatitis

Efficacy of telbivudine combined with adefovir dipivoxil and pegylated interferon combined with entecavir as antiviral therapy for chronic hepatitis B: a comparative analysis

Li Na, Gou Wei, Cui WeiLi

2016, 32(9): 1714-1716. DOI: 10.3969/j.issn.1001-5256.2016.09.015

Abstract(3247)

PDF (1509KB)(440)

Abstract:
Objective To investigate the efficacy of telbivudine combined with adefovir dipivoxil and PEG- IFN- α- 2a combined with entecavir as the antiviral therapy for HBe Ag- positive patients with chronic hepatitis B( CHB) and a high viral load. Methods A total of 80 previously untreated HBe Ag- positive C...

Clinical features of chronic HBV/HCV infection complicated by mild hepatic steatosis

He Jia, Li Wei, Li Kuan, Ning HuiBin, Liu JunPing, Mao ZhongShan, Shang Jia

2016, 32(9): 1717-1720. DOI: 10.3969/j.issn.1001-5256.2016.09.016

Abstract(2599)

PDF (1521KB)(454)

Abstract:
Objective To investigate the clinical features of previously untreated patients with chronic HBV/HCV infection complicated by mild hepatic steatosis. Methods A total of 111 previously untreated patients with chronic HBV/HCV infection who were hospitalized in Zhengzhou University People's Hospital fr...

Association of programmed cell death-1 gene polymorphisms with chronic hepatitis C virus infection and antiviral effect

Kong LingBo, Nan YueMin, Zhang YuGuo, Zhao SuXian, Wang RongQi, Fu Na, Di HaiLing, Su ShanShan

2016, 32(9): 1721-1724. DOI: 10.3969/j.issn.1001-5256.2016.09.017

Abstract(2192)

PDF (1515KB)(452)

Abstract:
Objective To investigate the association of single nucleotide polymorphisms( SNPs) of programmed cell death- 1( PD- 1)gene with chronic hepatitis C virus( HCV) infection and the effect of antiviral therapy with interferon combined with ribavirin. Methods A total of 228 patients with chronic hepatiti...

Efficacy comparative of different laboratory test reagents for hepatitis C virus antibody

Guo FeiBo, Wu JunZhu

2016, 32(9): 1725-1728. DOI: 10.3969/j.issn.1001-5256.2016.09.018

Abstract(2212)

PDF (1641KB)(436)

Abstract:
Objective To investigate the effects of different laboratory test reagents for hepatitis C virus( HCV) antibody through a comparative analysis. Methods A total of 207 samples which tested positive by four anti- HCV screening reagents commonly used in the laboratories in China( Kehua,Xinchuang,Wantai...

Effect of prohibitin on hepatitis C virus replication

Shi JuanJuan, Yang Ning, Zhang Xin, Wu FengPing, Li Mei, Gao Ning, Jia XiaoLi, Zhai Song, Dang ShuangSuo

2016, 32(9): 1729-1733. DOI: 10.3969/j.issn.1001-5256.2016.09.019

Abstract(2071)

PDF (1901KB)(437)

Abstract:
Objective To investigate the effect of prohibitin( PHB) on hepatitis C virus( HCV) replication. Methods Human hepatocarcinoma Huh- 7. 5 cells were transfected with the full- length genome HCV RNA in vitro to establish the full- length genome cell model of HCV,and the supernatants were collected 24,4...

Original articles_Liver fibrosis and liver cirrhosis

Effect of entecavir combined with Fuzheng Huayu capsules on inflammatory factors and fibrosis markers in patients with compensated chronic hepatitis B-related cirrhosis

Wang He, Wang QianJun, Sun FengBo, Zhang XinMing, Qi YuQin

2016, 32(9): 1734-1738. DOI: 10.3969/j.issn.1001-5256.2016.09.020

Abstract(2495)

PDF (1538KB)(458)

Abstract:
Objective To investigate the clinical effect of entecavir( ETV) combined with Fuzheng Huayu capsules in the treatment of patients with compensated chronic hepatitis B- related cirrhosis. Methods A total of 142 patients with compensated chronic hepatitis B- related cirrhosis who visited the Sixth Peo...

Value of indocyanine green test in evaluating liver reserve function in patients with hepatitis B cirrhosis

Lai RuiMin, Wang MingFang, Zhu YueYong

2016, 32(9): 1739-1742. DOI: 10.3969/j.issn.1001-5256.2016.09.021

Abstract(2532)

PDF (1642KB)(458)

Abstract:
Objective To evaluate liver reserve function in patients with hepatitis B cirrhosis using indocyanine green( ICG) clearance test,and to investigate the correlation of ICG clearance test with Child- Turcotte- Pugh( CTP) class and the Model for End- Stage Liver Disease( MELD) score in evaluating liver...

Clinical effect of laparoscopic splenectomy combined with esophagogastric devascularization in treatment of liver cirrhosis with portal hypertension

Tang HanQiu

2016, 32(9): 1743-1746. DOI: 10.3969/j.issn.1001-5256.2016.09.022

Abstract(2267)

PDF (1518KB)(410)

Abstract:
Objective To investigate the effect and safety of laparoscopic splenectomy( LS) combined with esophagogastric devascularization( ED) in the treatment of esophagogastric variceal bleeding and severe hypersplenism. Methods A retrospective analysis was performed for 68 patients with cirrhotic portal hy...

Original articles_Liver neoplasms

Elemene combined with transcatheter arterial chemoembolization in treatment of primary liver cancer: a meta-analysis

Ou ZhiTao, Zhan YuanJing, Huang ChunMing

2016, 32(9): 1747-1752. DOI: 10.3969/j.issn.1001-5256.2016.09.023

Abstract(1705)

PDF (2109KB)(348)

Abstract:

Objective To investigate the short- term efficacy,long- term efficacy,and adverse effects of elemene combined with transcatheter arterial chemoembolization( TACE) in the treatment of primary liver cancer( PLC). Methods Pub Med,EMBASE,Cochrane Library,Chinese Scientific Journal Full- Text Database,Wa...

Original articles_Biliary diseases

Value of endoscopic ultrasound and magnetic resonance cholangiopancreatography in diagnosis of obstructive jaundice

Jia Lei, Guo YuNing, Guo XiuLi, Wang TianYi, Lu: Dong, Xu YouQing

2016, 32(9): 1753-1755. DOI: 10.3969/j.issn.1001-5256.2016.09.024

Abstract(2516)

PDF (1502KB)(446)

Abstract:

Objective To investigate the value of endoscopic ultrasound( EUS) versus magnetic resonance cholangiopancreatography( MRCP) in the diagnosis of obstructive jaundice. Methods A total of 31 patients with obstructive jaundice who visited Beijing Tiantan Hospital,Capital Medical University,from January ...

Clinical experience in treatment of complex intrahepatic bile duct stones by regular hepatectomy

Wu Xiao, Xia Hao, Wu Jian, Zhang Ming

2016, 32(9): 1756-1759. DOI: 10.3969/j.issn.1001-5256.2016.09.025

Abstract(2472)

PDF (1607KB)(462)

Abstract:

Objective To investigate the clinical effect of regular hepatectomy in patients with complex intrahepatic bile duct stones. Methods A retrospective analysis was performed for the clinical data of 98 patients with complex intrahepatic bile duct stones who were treated in our hospital from January to ...

Operation skills of endoscopic retrograde cholangiopancreatography in pancreaticobiliary patients with periampullary duodenal diverticula

Zhuang DongHai, Zhang Kai

2016, 32(9): 1760-1762. DOI: 10.3969/j.issn.1001-5256.2016.09.026

Abstract(2371)

PDF (1775KB)(422)

Abstract:
Objective To investigate the operation skills of endoscopic retrograde cholangiopancreatography( ERCP) in patients with periampullary duodenal diverticula. Methods A retrospective analysis was performed for the clinical data of 867 patients with periampullary duodenal diverticula who underwent ERCP ...

Original articles_Pancreatic diseases

Diagnosis and treatment of hypertriglyceridemic pancreatitis in pregnancy

Gao NaNa

2016, 32(9): 1763-1765. DOI: 10.3969/j.issn.1001-5256.2016.09.027

Abstract(1717)

PDF (1497KB)(399)

Abstract:
Objective To investigate the clinical diagnosis and treatment of hypertriglyceridemic pancreatitis in pregnancy( HPP). Methods The clinical data of 29 patients with HPP who were admitted to Yulin Hospital of Traditional Chinese Medicine from June 2005 to June2015 were retrospectively analyzed. Resul...

Original articles_Others

Clinical features of HBV-associated acute-on-chronic liver failure induced by discontinuation of nucleoside analogues

Liu XiaoYan, Chen Jing, Xiao Long, Tong JingJing, Guan ChongDan, Yan LiLong, Su HaiBin

2016, 32(9): 1766-1769. DOI: 10.3969/j.issn.1001-5256.2016.09.028

Abstract(2142)

PDF (1525KB)(444)

Abstract:

Objective To investigate the clinical features of patients with HBV- associated acute- on- chronic liver failure( HBV-ACLF) induced by the discontinuation of necleos( t) ide analogues. Methods A retrospective analysis was performed for 698 patients with a definite diagnosis of HBV- ACLF in The 302 H...

Decompensated liver disease complicated by acute stroke caused by multiple factors: a clinical analysis of 15 cases

Gou ChunYan, Li Li, Zhao DaWei, Li JingYing, Luo XiaoLan, Li XiuHui

2016, 32(9): 1770-1773. DOI: 10.3969/j.issn.1001-5256.2016.09.029

Abstract(1976)

PDF (1653KB)(426)

Abstract:

Objective To investigate the clinical features of patients with decompensated liver disease complicated by acute stroke. Methods A retrospective analysis was performed for the clinical data of 15 patients who were hospitalized in Beijing You'an Hospital,Capital Medical University and diagnosed with ...

Association between serum preptin level and insulin resistance in patients with nonalcoholic fatty liver disease

Wang JinJun, Wang QinQin, Liu XinYan, Li YingMei, Xiong WuJun

2016, 32(9): 1774-1777. DOI: 10.3969/j.issn.1001-5256.2016.09.030

Abstract(2044)

PDF (1555KB)(407)

Abstract:

Objective To investigate the change in serum preptin level and its association with insulin resistance( IR) in patients with nonalcoholic fatty liver disease( NAFLD). Methods A total of 72 patients with NAFLD who visited the outpatient service or were hospitalized in Putuo Hospital Affiliated to Sha...

Effect of blueberry and probiotics on expression of PNPLA3 and SREBP-1c in rats with nonalcoholic fatty liver disease

Zhu JuanJuan, Zhou MingYu, Cheng MingLiang

2016, 32(9): 1778-1784. DOI: 10.3969/j.issn.1001-5256.2016.09.031

Abstract(2267)

PDF (2000KB)(460)

Abstract:

Objective To investigate the expression of patatin- like phospholipase domain- containing protein 3( PNPLA3) and sterol regulatory element- binding protein- 1c( SREBP- 1c) in the rat model of nonalcoholic fatty liver disease( NAFLD) treated by blueberry combined with probiotics,as well as its mechan...

Case reports

Drug hypersensitivity syndrome with liver failure as the main clinical manifestation: a case report

Han DongXia, Li Juan, Meng QingHua

2016, 32(9): 1785-1786. DOI: 10.3969/j.issn.1001-5256.2016.09.032

Abstract(2335)

PDF (1722KB)(482)

Abstract:

A case of acute fulminant hepatitis B with HIV infection

Chen ChiChi, Chen XiaoRong, Lu YunFei

2016, 32(9): 1787-1788. DOI: 10.3969/j.issn.1001-5256.2016.09.033

Abstract(2061)

PDF (1718KB)(454)

Abstract:

A case of secondary hemochromatosis

Mou WenQian, Li ChunYan, Chen YanPing

2016, 32(9): 1789-1790. DOI: 10.3969/j.issn.1001-5256.2016.09.034

Abstract(2216)

PDF (1481KB)(454)

Abstract:

A case of primary systemic amyloidosis with hepatomegaly as the main manifestation

Fan ChunLei, Wang Zheng, Li Lei, Dong PeiLing, Ding HuiGuo

2016, 32(9): 1791-1793. DOI: 10.3969/j.issn.1001-5256.2016.09.035

Abstract(2147)

PDF (1563KB)(422)

Abstract:

Reviews

The role of fluoxetine in antiviral therapy for chronic hepatitis C

Qin Yuan, Zhang Ying, Zhao JieRu, Guo YongHong, Jia ZhanSheng

2016, 32(9): 1794-1796. DOI: 10.3969/j.issn.1001-5256.2016.09.036

Abstract(2082)

PDF (1509KB)(428)

Abstract:

More than 20% of chronic hepatitis C( CHC) patients receiving the antiviral therapy with interferonα( IFNα) experience depression,and fluoxetine is often used to alleviate this symptom. Fluoxetine has anti- inflammatory properties and can change the synthesis of liver lipids,but its influence on ant...

Research advances in indicators for early diagnosis of liver cirrhosis patients with renal impairment

Lu LiFang, Feng GuoHe

2016, 32(9): 1797-1800. DOI: 10.3969/j.issn.1001-5256.2016.09.037

Abstract(2228)

PDF (1517KB)(490)

Abstract:
The liver is closely associated with the kidney,and liver injury in various stages can cause various kidney diseases to varying degrees,which further lead to renal impairment. Such renal impairment in the early stage is often functional and can be reversed by drugs,otherwise it can progress to hepat...

Research advances in integrated traditional Chinese and Western medicine diagnosis and treatment of minimal hepatic encephalopathy

Sun RunFei, Wu Chao, Chen Xi, Sun MingYu

2016, 32(9): 1801-1805. DOI: 10.3969/j.issn.1001-5256.2016.09.038

Abstract(2297)

PDF (1581KB)(490)

Abstract:

Minimal hepatic encephalopathy( MHE) is a common complication in the progression of liver cirrhosis,and cando great harm to patients and the society. This disease has hidden clinical symptoms,and fine intelligence tests and nerve electrophysiological examination can find abnormalities in intelligenc...

Current research status of mechanisms of the development and progression of liver fibrosis

Xu MingCui, Zhang Feng, Zhu GeYuZheng

2016, 32(9): 1806-1809. DOI: 10.3969/j.issn.1001-5256.2016.09.039

Abstract(2219)

PDF (1509KB)(486)

Abstract:

Liver fibrosis is the intermediate process in the progression of various chronic liver diseases to liver cirrhosis,and its serious complications affect the prognosis of patients with chronic liver diseases. However,so far,there remain no effective drugs for the treatment of liver fibrosis. This arti...

The role of MAPK signaling pathway in development/progression and treatment of liver cancer

Ci DanWangJiu, Lin Kun, Lu ZaiMing, Zhao XiangXuan, Wang XiaoMing

2016, 32(9): 1810-1813. DOI: 10.3969/j.issn.1001-5256.2016.09.040

Abstract(2448)

PDF (1521KB)(511)

Abstract:

Abnormal activation of the mitogen- activated protein kinase( MAPK) signaling pathway is closely associated with the development,progression,and metastasis of liver cancer. This article introduces the expression of MAPK proteins in liver cancer and its role in the proliferation,differentiation,and m...

Role of uric acid in the development and progression of nonalcoholic fatty liver disease

Li ShaoFeng, Liao XianHua, Ye JunZhao, Zhong BiHui

2016, 32(9): 1814-1818. DOI: 10.3969/j.issn.1001-5256.2016.09.041

Abstract(2339)

PDF (1533KB)(513)

Abstract:
Abnormal uric acid metabolism is closely associated with the development and progression of nonalcoholic fatty liver disease( NAFLD). This article describes the relationship between uric acid and the prevalence and severity of NAFLD,and point out that uric acid metabolic disorders directly affect th...

Research advances in diagnosis and treatment of IgG4-associated autoimmune hepatitis

Shi XiaoDong, Wei Qi, Yu Min, Liu XingXing, Jia ZhiFang, Wang YueQi, Jiang ZhenYu

2016, 32(9): 1819-1821. DOI: 10.3969/j.issn.1001-5256.2016.09.042

Abstract(1947)

PDF (1698KB)(492)

Abstract:
Autoimmune hepatitis( AIH) is a chronic progressive inflammatory disease involving the liver parenchyma. In recent years,there have been more studies focusing on IgG4- associated diseases. Foreign scholars have found that patients with AIH also have IgG4- positive plasma cell infiltration in the liv...

Research progress in biomarkers of drug-induced liver injury

Guo Pei, Lu Wang, Yang WenXuan, Hu YuLin

2016, 32(9): 1822-1826. DOI: 10.3969/j.issn.1001-5256.2016.09.043

Abstract(1609)

PDF (1530KB)(396)

Abstract:

Drug- induced liver injury( DILI) is a major reason for the recall of marketed drugs and the failure of clinical trials. Detection of potential liver injury remains a challenge for clinical management and preclinical drug safety studies. Currently,serum levels of alanine aminotransferase and asparta...

Research progress in the role of autophagy in liver regeneration

Han WeiJia, Shi HongBo, Chen Yu

2016, 32(9): 1827-1831. DOI: 10.3969/j.issn.1001-5256.2016.09.044

Abstract(2078)

PDF (1521KB)(419)

Abstract:

Autophagy is a pathway of intracellular degradation,in which autophagic vacuoles are formed to transport intracellular biomacromolecules and damaged organelles to lysosomes. Autophagy plays an important role in the maintenance of the dynamic balance of liver function. Abnormal liver cells can be eli...