2019 No. 1

2019 Vol. 35, No. 1

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Editorial

Etiological diagnosis and standard treatment of portal hypertension should be taken seriously

Zhao LianHui, Jia JiDong

2019, 35(1): 10-12. DOI: 10.3969/j.issn.1001-5256.2019.01.001

Abstract(1942)

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Abstract:
Portal hypertension (PH) referes to an abnormal increase in portal venous pressure due to increased resistance and/or blood flow of the portal vein or backflow obstruction of the hepatic veins and often manifests as splenomegaly, hypersplenism, gastroesophageal varices and bleeding, ascites, and hep...

Discussions by experts

Diagnosis and treatment of pre-hepatic (sinusoidal) non-cirrhotic portal hypertension and related difficulties

Xu HangFei, Ding HuiGuo

2019, 35(1): 13-17. DOI: 10.3969/j.issn.1001-5256.2019.01.002

Abstract(670)

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Abstract:
Pre-hepatic (sinusoidal) non-cirrhotic portal hypertension is a group of vascular heterogeneous diseases with portal hypertension as the prominent manifestation and has a complex etiology.Compared with the patients with cirrhotic portal hypertension, the patients with prehepatic (sinusoidal) non-cir...

Advances in the diagnosis and treatment of non-cirrhotic sinusoidal portal hypertension

Chen YongPeng

2019, 35(1): 18-23. DOI: 10.3969/j.issn.1001-5256.2019.01.003

Abstract(494)

PDF (262KB)(41)

Abstract:

The common causes of non-cirrhotic sinusoidal hypertension were intrahepatic diseases that involves sinusoidal or perisinusoidal space, with sinusoidal obstruction syndrome being a common etiology, which was mainly caused by chemotherapy or radiotherapy prior to hematopoietic stem cell transplantati...

Diagnosis and treatment of post-hepatic portal hypertension

Liu Lei, Ye Qing, Han Tao

2019, 35(1): 24-28. DOI: 10.3969/j.issn.1001-5256.2019.01.004

Abstract(2086)

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Abstract:
Post-hepatic portal hypertension refers to portal hypertension caused by the obstruction of liver blood flow between the extrahepatic liver vein and the right heart due to the obstruction of the extrahepatic liver vein.Common etiologies include Budd-Chiari syndrome, right heart failure, and constric...

Diagnosis and treatment of portal hypertension caused by rare diseases

Wang Yu, Wang Min, Ou XiaoJuan, Jia JiDong

2019, 35(1): 29-32. DOI: 10.3969/j.issn.1001-5256.2019.01.005

Abstract(1849)

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Abstract:
Portal hypertension caused by rare diseases is mostly presinusoidal (prehepatic) or posthepatic.It is non-cirrhotic portal hypertension in most cases, so hepatic venous pressure gradient cannot accurately reflect the portal venous pressure of such patients, which causes difficulties in clinical diag...

Noninvasive examinations of portal hypertension

Lin ShanShan, Liu YanNa, Qi XiaoLong

2019, 35(1): 33-37. DOI: 10.3969/j.issn.1001-5256.2019.01.006

Abstract(2065)

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Abstract:
As a common clinical syndrome, portal hypertension can cause severe complications including gastroesophageal varices, ascites, and hepatic encephalopathy in patients with chronic liver diseases, which indirectly affects the prognosis of cirrhotic patients.At present, hepatic venous pressure gradient...

Therapeutic guidelines

Guideline for diagnosis and treatment of liver failure(2018)

Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association; Severe Liver Disease and Artificial Liver Group, Chinese Society of Hepatology, Chinese Medical Association

2019, 35(1): 38-44. DOI: 10.3969/j.issn.1001-5256.2019.01.007

Abstract(2092)

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Abstract:

Guideline for the diagnosis and treatment of chronic pancreatitis (2018, Guangzhou)

Chronic Pancreatitis Group of Pancreatic Disease Committee of Chinese Medical Doctor Association

2019, 35(1): 45-51. DOI: 10.3969/j.issn.1001-5256.2019.01.008

Abstract(1311)

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Abstract:

Recommendations for hepatitis C guidance: AASLD-IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus(2018)

Jin ChunXue, Jiang MengShu, Wang Fang, Xu YaJie, Liu ShuJing, Zhao Ping

2019, 35(1): 52-58. DOI: 10.3969/j.issn.1001-5256.2019.01.009

Abstract(413)

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Abstract:

An excerpt of WFSUMB guidelines and recommendations on the clinical use of liver ultrasound elastography, update 2018 (short version)

Fu TianTian, Ding Hong

2019, 35(1): 59-63. DOI: 10.3969/j.issn.1001-5256.2019.01.010

Abstract(604)

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Abstract:

An excerpt of the recommendations of international liver transplantation society for management and treatment of nonalcoholic steatohepatitis (2018)

Zhang XiaXia, Xu YouQing

2019, 35(1): 64-66. DOI: 10.3969/j.issn.1001-5256.2019.01.011

Abstract(418)

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Abstract:

An excerpt of pancreatic cancer: French clinical practice guidelines for diagnosis, treatment and follow-up(2018)

Ma YongSu, Yang YinMo

2019, 35(1): 67-71. DOI: 10.3969/j.issn.1001-5256.2019.01.012

Abstract(472)

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Abstract:

An excerpt of IAP/APA/JPS/EPC guidelines for the diagnostic cross sectional imaging and severity scoring of chronic pancreatitis (2018)

Mao YiShen, Xie ZhiBo, Fu DeLiang

2019, 35(1): 72-76. DOI: 10.3969/j.issn.1001-5256.2019.01.013

Abstract(385)

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Abstract:

Original articles_Viral hepatitis

Liver inflammatory activity in chronic hepatitis B patients with a low HBV DNA level and related factors

Liu Li, Liu ChunYun, Du YingRong, Huang HongLi, Chen Jie, Luo Yu, Li HuiMin, Li WeiKun, Li JunYi, Yue YunXuan

2019, 35(1): 77-81. DOI: 10.3969/j.issn.1001-5256.2019.01.014

Abstract(1561)

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Abstract:
Objective To investigate the association between liver inflammatory activity and clinical features in chronic hepatitis B (CHB) patients with a low HBV DNA level, and to provide a basis for judging the condition of such patients.Methods A total of 137 patients with an HBV DNA level of 20-2000 IU/ml ...

Original articles_Liver fibrosis and liver cirrhosis

Clinical effect of human serum albumin versus artificial colloidal fluid in patients with cirrhotic ascites undergoing drainage:A Meta-analysis

Yang Jun, Ning QiQi, Wu Jing, Li Juan, Zhu YueKe, Yu HongWei, Meng QingHua, Hu ZhongJie

2019, 35(1): 82-86. DOI: 10.3969/j.issn.1001-5256.2019.01.015

Abstract(1816)

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Abstract:
Objective To investigate the clinical effect of infusion of albumin versus artificial colloidal fluid after ascites drainage in patients with liver cirrhosis and ascites.Methods Cochrane Library (from 1993 to February 2018) PubMed (from 1966 to February 2018) , Embase (from 1990 to February 2018) , ...

Value of four scoring systems in evaluating the prognosis of cirrhotic patients with infection

Yao YunHai, Gan JianHe, Zhao WeiFeng

2019, 35(1): 87-91. DOI: 10.3969/j.issn.1001-5256.2019.01.016

Abstract(2152)

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Abstract:
Objective To investigate the value of Child-Turcotte-Pugh (CTP) score, Model for End-Stage Liver Disease (MELD) score, chronic liver failure-sequential organ failure assessment (CLIF-SOFA) score, and APASL-ACLF Research Consortium (AARC) score in evaluating the prognosis of cirrhotic patients with i...

Risk factors for early rebleeding after initial sclerotherapy for esophageal varices

Sun YaNan, Li Peng, Ding HuiGuo, Zhang ShiBin, Xiong Feng

2019, 35(1): 92-97. DOI: 10.3969/j.issn.1001-5256.2019.01.017

Abstract(1829)

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Abstract:

Objective To investigate the effect of initial esophageal variceal sclerotherapy (EVS) on liver function and blood biochemistry in patients with liver cirrhosis and the risk factors for early rebleeding after initial EVS.Methods A retrospective analysis was performed for the clinical data of 120 cir...

Original articles_Liver neoplasms

Clinical effect of transcatheter arterial chemoembolization combined with local thermal ablation in treatment of large hepatocellular carcinoma and related influencing factors

Xing AiLi, Zheng JiaSheng

2019, 35(1): 98-103. DOI: 10.3969/j.issn.1001-5256.2019.01.018

Abstract(2037)

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Abstract:

Objective To investigate the clinical effect of transcatheter arterial chemoembolization (TACE) combined with local thermal ablation in the treatment of large hepatocellular carcinoma (HCC) .Methods A retrospective analysis was performed for the clinical data of134 patients with large HCC who underw...

Effect of sorafenib combined with transcatheter arterial chemoembolization and radiofrequency ablation on the survival of patients with hepatocellular carcinoma

Sun Bin, Yang XiaoZhen, Xie Fang, Pang LiJun, Chen DeXi, Wang YanJun

2019, 35(1): 104-108. DOI: 10.3969/j.issn.1001-5256.2019.01.019

Abstract(2184)

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Abstract:
Objective To analyze the effect of sorafenib combined with transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) on the survival of patients with hepatocellular carcinoma (HCC) and its prognostic factors.Methods A retrospective analysis was performed on 221 HCC patients w...

Changes in alpha-fetoprotein and des-γ-carboxy-prothrombin after transarterial chemoembolization and their value in predicting treatment outcome

Yan LeLe, Ni CaiFang, Li Zhi, Hu Bo, Xu JiaChen

2019, 35(1): 109-113. DOI: 10.3969/j.issn.1001-5256.2019.01.020

Abstract(1902)

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Abstract:

Objective To investigate the value of alpha-fetoprotein (AFP) combined with des-γ-carboxy-prothrombin (DCP) in predicting the therapeutic effect of transarterial chemoembolization (TACE) .Methods A retrospective analysis was performed for the clinical data of 85 patients with hepatocellular carcinom...

Surgical outcome and survival of patients with spontaneous rupture and bleeding of hepatocellular carcinoma after hepatectomy

Wang XinWei, Wang WeiNa, Zhang ZongLi

2019, 35(1): 114-118. DOI: 10.3969/j.issn.1001-5256.2019.01.021

Abstract(1809)

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Abstract:

Objective To investigate the surgical outcome and survival of patients with spontaneous rupture and bleeding of hepatocellular carcinoma after hepatectomy.Methods A total of 68 patients with spontaneous rupture and bleeding of hepatocellular carcinoma who were admitted to Rizhao Municipal Hospital o...

Expression features and clinical significance of the microRNA-888 gene family in hepatocellular carcinoma

Huang XiangJun, Zhang WenXing

2019, 35(1): 119-122. DOI: 10.3969/j.issn.1001-5256.2019.01.022

Abstract(1839)

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Abstract:

Objective To investigate the expression features and clinical significance of the microRNA-888 (miRNA-888) gene family members in hepatocellular carcinoma (HCC) .Methods A total of 72 patients with pathologically confirmed HCC who were treated in The First Affiliated Hospital of Hunan University of ...

Expression and clinical significance of long non-coding RNA exocyst complex component 7 in hepatocellular carcinoma

Fang ZhangYing, Zhu ChuanWei, Zhang QingSong, He YongYong

2019, 35(1): 123-126. DOI: 10.3969/j.issn.1001-5256.2019.01.023

Abstract(1678)

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Abstract:

Objective To investigate the expression and clinical significance of long non-coding RNA (lncRNA) exocyst complex component 7 (EXOC7) in hepatocellular carcinoma (HCC) .MethodsA total of 79 pairs of HCC tissue samples and adjacent tissue samples were collected from the patients who underwent HCC sur...

Original articles_Biliary diseases

Value of endoscopic ultrasonography combined with magnetic resonance cholangiopancreatography in diagnosis of patients suspected of common bile duct stones

Wang Chao, Xu Feng, Dai ChaoLiu

2019, 35(1): 127-130. DOI: 10.3969/j.issn.1001-5256.2019.01.024

Abstract(1798)

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Abstract:

Objective To investigate whether endoscopic ultrasonography (EUS) combined with magnetic resonance cholangiopancreatography (MRCP) can improve the diagnostic efficiency of such combination in the diagnosis of patients suspected of common bile duct stones.Methods A retrospectively analysis was perfor...

Clinical effect of biliary stenting combined with percutaneous transhepatic cholangial drainage in treatment of different types of malignant obstructive jaundice

Liu Rui, Huang Kun, Chen WeiWei, Han ShanShan, Liu ChengLi

2019, 35(1): 131-137. DOI: 10.3969/j.issn.1001-5256.2019.01.025

Abstract(2194)

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Abstract:

Objective To investigate the clinical effect and surgical experience of percutaneous transhepatic cholangial drainage (PTCD) combined with biliary stenting in patients with different types of malignant obstructive jaundice (MOJ) .Methods A retrospective analysis was performed for the early clinical ...

Original articles_Pancreatic diseases

Clinical features and prognosis of acute pancreatitis in pregnancy

Yuan Jing, Meng Fei, Tang XiaoWei, Chen Xia, Peng Yan

2019, 35(1): 138-142. DOI: 10.3969/j.issn.1001-5256.2019.01.026

Abstract(1858)

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Abstract:

Objective To investigate the preventive and treatment measures for acute pancreatitis in pregnancy (APIP) , and to improve the awareness of this disease.Methods A total of 65 patients with APIP who were admitted to The Affiliated Hospital of Southwest Medical U-niversity from January 2013 to Decembe...

Clinical effect of Cyber Knife radiosurgery in locally advanced pancreatic cancer or pancreatic cancer with distant metastasis

Zhang AiMin, Chang XiaoYun, Li WenGang, Han Ping, Xue Hui, Wang Hui, Duan XueZhang

2019, 35(1): 143-146. DOI: 10.3969/j.issn.1001-5256.2019.01.027

Abstract(2276)

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Abstract:
Objective To investigate the clinical effect of CyberKnife radiosurgery in locally advanced pancreatic cancer or pancreatic cancer with distant metastasis.Methods A retrospective analysis was performed for the clinical data of 32 patients with pancreatic cancer who were treated with CyberKnife radio...

Original articles_Others

Clinical outcome of patients with acute-on-chronic liver failure and bacterial infection after 72 hours of anti-infective therapy

Li Chen, Su HaiBin, Liu XiaoYan, Xu Xiang, Li Hui, Peng YuHui, Yan LiLong

2019, 35(1): 147-152. DOI: 10.3969/j.issn.1001-5256.2019.01.028

Abstract(572)

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Abstract:

Objective To investigate the clinical outcome of patients with acute-on-chronic liver failure (ACLF) and bacterial infection on admission after 72 hours of anti-infective therapy and related influencing factors.Methods An electronic database was used to select267 patients with ACLF and bacterial inf...

Clinical effects of bone marrow stem cell transplantation through different approaches in mice with acute liver injury

Mu LiYa, Tang XiuFen, Li ShuQin, Yu Dan, Sun YuanYuan, Zhao JinHua

2019, 35(1): 153-156. DOI: 10.3969/j.issn.1001-5256.2019.01.029

Abstract(1782)

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Abstract:

Objective To investigate the migration of bone marrow stem cells (BMSCs) to the liver and liver repair in mice with acute liver injury treated with BMSC transplantation through four approaches.Methods Male BALB/c mice were divided into groups A, B, C, D, E, and F, with 10 mice in each group.Groups A...

Effect of erythropoietin on the mRNA expression of apoptosis genes bcl-2 and bax in rats with fatty liver disease after hepatic ischemia-reperfusion injury

Li Yang, Shu DeJun, Peng CiJun, Feng ZanJie, Mei Yong, Xiong Kun

2019, 35(1): 157-160. DOI: 10.3969/j.issn.1001-5256.2019.01.030

Abstract(479)

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Abstract:

Objective To investigate the effect of erythropoietin (EPO) on the mRNA expression of apoptosis genes bcl-2 and bax in rats with fatty liver disease after hepatic ischemia-reperfusion injury.Methods A total of 100 male adult Sprague-Dawley rats were fed with high-fat diet for 12 weeks.After the mode...

Brief reports

Effect of statins on hepatocellular carcinoma in patients with type 2 diabetes

Shi Feng, Lei YuPeng

2019, 35(1): 161-163. DOI: 10.3969/j.issn.1001-5256.2019.01.031

Abstract(1092)

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Abstract:

Case reports

Direct-acting antiviral durgs for hepatitis C in children: A case report

Ning HuiBin, Liu JunPing, Jin HuiMing, Li Kuan, Xiao ErHui, Shang Jia

2019, 35(1): 164-165. DOI: 10.3969/j.issn.1001-5256.2019.01.032

Abstract(1529)

PDF (1997KB)(346)

Abstract:

Autosomal recessive polycystic kidney disease with congenital hepatic fibrosis: A report of 3 cases in a pedigree and literature review

Cao LiLi, Dong Yi, Xu ZhiQiang, Chen DaWei, Wang FuChuan, Gan Yu, Wang LiMin, Yan JianGuo, Wang Pu, Li AiQin, Zhang Min

2019, 35(1): 166-168. DOI: 10.3969/j.issn.1001-5256.2019.01.033

Abstract(489)

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Abstract:

A case of non-cirrhotic portal hypertension

Tang XiaoTing, He QinJun, Chen JinJun

2019, 35(1): 169-171. DOI: 10.3969/j.issn.1001-5256.2019.01.034

Abstract(1375)

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Abstract:

Intrahepatic portal-hepatic venous fistula: A case report

Jiang Lan, Xu ChunFang

2019, 35(1): 172-173. DOI: 10.3969/j.issn.1001-5256.2019.01.035

Abstract(1244)

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Abstract:

A case of Abernethy malformation type 2

Dai HaiMei, Li Hui, Wei Jia

2019, 35(1): 174-176. DOI: 10.3969/j.issn.1001-5256.2019.01.036

Abstract(1326)

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Abstract:

Non-Hodgkin lymphoma with polyserositis as the main manifestation: A case report

Dong HongJing, Li YanQing, Li WanYu, Gao YanHang

2019, 35(1): 177-178. DOI: 10.3969/j.issn.1001-5256.2019.01.037

Abstract(1314)

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Abstract:

A case of antimitochondrial antibody-negative primary biliary cholangitis

Zhang LiXia, Huang Xu, Sun XiaoJie, Zhang Ying, Lu ShaSha, Shi XiaoDong, Ji HuiFan, Guo XiaoLin

2019, 35(1): 179-181. DOI: 10.3969/j.issn.1001-5256.2019.01.038

Abstract(1540)

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Abstract:

A case of IgG4-related disease with the main manifestation in both lower mandibles

Bi YaRu, Jiao ZiXuan, Jin QingLong, Wen XiaoYu, Guo YuYing

2019, 35(1): 182-184. DOI: 10.3969/j.issn.1001-5256.2019.01.039

Abstract(403)

PDF (331KB)(153)

Abstract:

Endoscopic pancreatic stent placement combined with tumor enucleation for benign pancreatic neck tumor: A case report

Wang Kun, ABUDUREYIMU·Tuerhong, Yang Fan, Liu YaHui, Fu Yu, Zhang Wei

2019, 35(1): 185-186. DOI: 10.3969/j.issn.1001-5256.2019.01.040

Abstract(1676)

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Reviews

Research advances in direct-acting antiviral agents in the treatment of hepatitis C virus-related liver cirrhosis

You GuoQiong, Wang Li, Duan Meng, Zhu Peng

2019, 35(1): 187-190. DOI: 10.3969/j.issn.1001-5256.2019.01.041

Abstract(1406)

PDF (1974KB)(338)

Abstract:

Liver cirrhosis is common in clinical practice and is the common clinical outcome of various chronic liver diseases including chronic hepatitis C virus (HCV) infection.Before the development of direct-acting antiviral agents (DAAs) , anti-HCV therapy based on pegylated interferon (PEG-IFN.) and riba...

Research advances in hepatitis B cirrhosis with renal injury and the application of antiviral drugs

Zhang JieBing, Guo HongHua

2019, 35(1): 191-196. DOI: 10.3969/j.issn.1001-5256.2019.01.042

Abstract(1297)

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Abstract:

Hepatitis B cirrhosis is a chronic progressive disease caused by hepatitis B virus (HBV) infection and has various complications such as upper gastrointestinal bleeding, hepatic encephalopathy, and hepatorenal syndrome, and it may progress to liver cancer and even cause death in severe cases.In addi...

Current status and prospects of research on noninvasive diagnosis of liver fibrosis

Zheng ShaoQiu, Wang QiZhi

2019, 35(1): 197-200. DOI: 10.3969/j.issn.1001-5256.2019.01.043

Abstract(1618)

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Abstract:

Liver fibrosis is a common pathological process in the progression of various chronic liver diseases to liver cirrhosis and liver cancer, and liver biopsy with the highest accuracy in diagnosis cannot be used as a routine examination due to several drawbacks.This article introduces several serologic...

Prognostic evaluation of transjugular intrahepatic portosystemic shunt in treatment of cirrhotic portal hypertension

Zou SongLong, Xu Ying

2019, 35(1): 201-204. DOI: 10.3969/j.issn.1001-5256.2019.01.044

Abstract(1736)

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Abstract:

Transjugular intrahepatic portosystemic shunt (TIPS) is an important method for the treatment of cirrhotic portal hypertension;however, its clinical application is limited by postoperative complications such as liver failure and hepatic encephalopathy.This article summarizes and analyzes the researc...

Role of intestinal flora in the development/progression and treatment of autoimmune liver diseases

Huang ChunYang, Chen Jie, Liu YanMin, Dan Jing

2019, 35(1): 205-207. DOI: 10.3969/j.issn.1001-5256.2019.01.045

Abstract(1796)

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Abstract:

Overgrowth of intestinal bacteria, change in intestinal flora, translocation between bacteria and their products, and bile acid metabolism are the important pathways for the development and progression of liver diseases.Hepatocytes are persistently exposed to intestinal metabolites and various antig...

Clinical features, pathogenesis, and diagnosis and treatment of different types of hepatic sinusoidal obstruction syndrome

Liu ZhenLi, Fan ZuoPeng, Gou YuSong, Liu YaLi, Zhang Jing

2019, 35(1): 208-212. DOI: 10.3969/j.issn.1001-5256.2019.01.046

Abstract(2435)

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Abstract:

Hepatic sinusoidal obstruction syndrome (HSOS) is a sinusoidal or small venous fibrous occlusive disease characterized by small hepatic vessel damage, especially sinusoidal endothelial cell injury.Exposure to certain exogenous toxins is the main cause of the disease.Based on etiology, HSOS is mainly...

Current research status of nosocomial infection in patients with severe liver diseases

Zhang Dan, Feng GuoHe

2019, 35(1): 213-216. DOI: 10.3969/j.issn.1001-5256.2019.01.047

Abstract(1441)

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Abstract:

Patients with severe liver diseases are prone to nosocomial infection due to serious liver dysfunction, low immune function, and reduced stress ability to infection, and such infections further aggravate patients’conditions and directly affect their clinical outcome.This article reviews the clinical...

The risk factors and prediction systems for posthepatectomy complications

Chen Long, Li Yue

2019, 35(1): 217-221. DOI: 10.3969/j.issn.1001-5256.2019.01.048

Abstract(2126)

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Abstract:

Hepatectomy has more complex surgical procedure and process than general surgeries.Although postoperative mortality of hepatectomy has been reduced significantly in this century, the incidence rate of postoperative complications remains at a high level.At present, there are fewer studies on risk fac...

Recent advances in digestive endoscopy in the field of pancreaticobiliary diseases

Cheng LiLi, Tang ChaoFeng, Zhao JiHang, Tang Xin, Ren GuoKun, Chen BenDong

2019, 35(1): 222-225. DOI: 10.3969/j.issn.1001-5256.2019.01.049

Abstract(1692)

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Abstract:

The clinical application of digestive endoscopic technique in the field of pancreaticobiliary diseases profoundly affects or even overturns many traditional thoughts.From endoscopic sphincterotomy and endoscopic biliary drainage to endoscopic ultrasonography-guided drainage and debridement of infect...