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CN 22-1108/R
Volume 40 Issue 3
Mar.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(3): 441-445

Chronic hepatitis B virus infection and metabolic associated fatty liver disease： The known and unknown aspects

DOI: 10.12449/JCH240301
  • 1.

    Department of Infectious Diseases，Affiliated Drum Tower Hospital of Nanjing University Medical School，Nanjing 210008，China

  • 2.

    Department of Infectious Diseases，Nanjing Drum Towel Hospital Clinical College of Nanjing University of Chinese Medicine，Nanjing 210008，China

Research funding:

General Project of National Natural Science Foundation of China (819705457);

General Project of National Natural Science Foundation of China (82170609);

General Project of National Science Foundation of Jiangsu Province (BK20231118)

More Information
  • Corresponding author: LI Jie， lijier@nju.edu.cn （ORCID： 0000-0003-0973-8645）
  • Received Date: 2023-12-30
  • Accepted Date: 2024-01-28
  • Published Date: 2024-03-20
    Abstract
  • Chronic hepatitis B virus （HBV） infection is the main cause of the disease burden of viral hepatitis worldwide， and meanwhile， due to changes in lifestyle and dietary habits， the incidence rate of metabolic associated fatty liver disease （MAFLD） is constantly increasing， making MAFLD the leading chronic liver disease around the world. Chronic HBV infection comorbid with MAFLD is becoming more and more common in clinical practice. Metabolic factors， rather than viral factors， are the main cause of chronic HBV infection comorbid with MAFLD. During disease progression， steatohepatitis and fibrosis， rather than steatosis， are the main influencing factors for the progression to liver cirrhosis and hepatocellular carcinoma. For patients with chronic HBV infection and MAFLD， integrated management of virus and metabolic factors is of great importance. This article reviews the tissues regarding the interaction， prognosis， and clinical management of chronic HBV infection and MAFLD.

     

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    • References(26)
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