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CN 22-1108/R
Volume 40 Issue 5
May  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(5): 1039-1043

Research advances in liver macrophages regulating malignant transformation of hepatic precancerous lesions

DOI: 10.12449/JCH240527
  • 1.

    Liver Disease Hospital Ward One，The Affiliated Hospital of Shaanxi University of Chinese Medicine，Xianyang，Shaanxi 712000，China

  • 2.

    First Clinical Medical College，Shaanxi University of Chinese Medicine，Xianyang，Shaanxi 712000，China

  • 3.

    Department of Infectious Diseases，People’s Hospital of Ningxia Hui Autonomous Region，Yinchuan 750002，China

Research funding:

National Natural Science Foundation of China (82174330);

Science and Technology Department of Shaanxi Research Fund (2022JQ-965);

Science and Technology Department of Shaanxi Research Fund (2020ZDLSF05-15);

Innovation Team of Science and Technology Department of Shaanxi Province (2022TD-55);

Innovation Team of TCM Administration of Shaanxi Province (2022-SLRH-LJ-002);

Science and Technology Administration of Xianyang City Scientific Research Fund (L2022ZDYFSF007);

Natural Science Foundation of Ningxia (2023AAC03510);

Discipline Innovation Team Building Project of Shaanxi University of Chinese Medicine (2019-YL05)

More Information
  • Corresponding author: GUO Yingjun， 510410652@qq.com （ORCID： 0009-0007-9766-5955）; LI Jingtao， lijingtao555@163.com （ORCID： 0000-0003-0417-9821）
  • Received Date: 2023-08-15
  • Accepted Date: 2023-09-12
  • Published Date: 2024-05-25
    Abstract
  • Liver macrophages are important immune cells in the liver， and they express proinflammatory factors and anti-inflammatory factors through polarization into M1 type and M2 type， respectively， thereby playing a role in regulating inflammatory damage response. The malignant transformation of hepatic progenitor cells is the core mechanism of the malignant progression of hepatic precancerous lesions， and its key factor is the continuous stimulation of inflammatory microenvironment， which is closely associated with M1/M2 macrophage polarization. This review mainly focuses on the association between macrophage polarization， chronic inflammation， and malignant transformation of hepatic progenitor cells， so as to provide a theoretical basis for the prevention and treatment of hepatic precancerous lesions.

     

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