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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 40 Issue 5
May  2024
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Article Contents

Role of β-glucuronidase in the formation of primary intrahepatic stones

DOI: 10.12449/JCH240530
Research funding:

Yunnan Province Department of Science and Technology-University Joint Fund Project (202101AY070001-129)

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  • Corresponding author: LI Jiang, 13888836057@163.com (ORCID: 0000-0002-6872-9434)
  • Received Date: 2023-08-23
  • Accepted Date: 2023-10-07
  • Published Date: 2024-05-25
  • Primary intrahepatic stones (PIS) is a refractory disease with a high incidence rate in Southwest China, which greatly affects the life of patients. Metabolites, such as β-glucuronidase produced by chronic biliary tract infection, play an important role in the formation of pigmented stones. In addition to exogenous β-glucuronidase produced by bacteria, endogenous β-glucuronidase produced by intrahepatic bile duct cells also plays an important role in the formation of stones. This article analyzes the research advances in the role of β-glucuronidase in the pathogenesis of PIS, in order to provide a possible method for the prevention and treatment of PIS.

     

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