Role of lipophagy in the prevention and treatment of nonalcoholic fatty liver disease

Zhili XIAO; Chenxia LU; Danni ZHOU; Zhuangzhuang CHEN; Mingzhong XIAO; Xiaodong LI

doi:10.12449/JCH240725

Volume 40 Issue 7

Jul. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(7): 1450-1458

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Role of lipophagy in the prevention and treatment of nonalcoholic fatty liver disease

DOI: 10.12449/JCH240725

Zhili XIAO¹,
Chenxia LU^{2, 3, 4},
Danni ZHOU^{2, 3, 4},
Zhuangzhuang CHEN¹,
Mingzhong XIAO^{1, 2, 3, 4
,
,
,},
Xiaodong LI^{2, 3, 4}

1.
The First Clinical College of Hubei University of Chinese Medicine，Wuhan 430061，China
2.
Department of Hepatology，The Affiliated Hospital of Hubei University of Chinese Medicine，Wuhan 430061，China
3.
Department of Hepatology，Hubei Provincial Hospital of Traditional Chinese Medicine，Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine，Wuhan 430061，China
4.
Hubei Academy of Chinese Medicine，Wuhan 430074，China

Research funding:

General Project of National Natural Science Foundation of China (82274352);

Natural Science Foundation of Hubei Province (2020CFA023);

Natural Science Foundation of Hubei Province (2023AFB426);

Natural Science Foundation of Hubei Province (2023AFD129);

Natural Science Foundation of Hubei Province (2023AFD178)

More Information

Corresponding author: XIAO Mingzhong， xmz0001@sohu.com （ORCID： 0000-0002-8432-703X）
Received Date: 2023-11-23
Accepted Date: 2023-12-22
Published Date: 2024-07-25

Abstract

Abstract

Nowadays， the prevalence of nonalcoholic fatty liver disease （NAFLD） is constantly rising in China and globally， and its incidence rate is increasing year by year， which has seriously affected human life and health. Lipophagy is molecular chaperone-mediated autophagy and has the functions of promoting lipolysis， maintaining the lipid homeostasis of hepatocytes， and alleviating hepatocyte fatty degeneration. Lipophagy has three main processes of lipid droplet catabolism， lipid droplet autophagy， and fatty acid β-oxidation， which are regulated by key genes， receptors， and enzymes. Currently， important advances have been achieved for the intervention methods of traditional Chinese medicine， Western medicine， diet， and exercise in the research on lipophagy， which provides new perspectives for the prevention and treatment strategies for NAFLD.
- Non-alcoholic Fatty Liver Disease,
- Autophagy,
- Therapeutics

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References(61)

References

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