The material basis and toxic mechanism of herb-induced liver injury

Xueying LIU; Huihui SHI; Haowen WANG; Tao YANG

doi:10.12449/JCH240802

Volume 40 Issue 8

Aug. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(8): 1512-1518

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The material basis and toxic mechanism of herb-induced liver injury

DOI: 10.12449/JCH240802

Xueying LIU¹,
Huihui SHI¹,
Haowen WANG¹,
Tao YANG^{1, 2
,
,
,}

1.
Cardiovascular Research Laboratory，Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai 201203，China
2.
Shanghai Key Laboratory of Traditional Chinese Clinical Medicine，Shanghai 201203，China

Research funding:

High-level Key Discipline Construction Project from State Administration of Traditional Chinese Medicine of China (zyyzdxk-2023060);

Shanghai TCM Development Three-Year Action Plan Project (ZY（2018-2020）-CCCX-5001);

Shanghai Science and Technology Innovation Action Plan Medical Innovation Research Special Project (20Z21900100);

Shanghai Key Specialty of Traditional Chinese Clinical Medicine (shslczdzk01201)

More Information

Corresponding author: YANG Tao， yangtao@shutcm.edu.cn （ORCID： 0000-0003-2355-1270）
Received Date: 2024-07-05
Accepted Date: 2024-07-18
Published Date: 2024-08-25

Abstract

Abstract

Herb-induced liver injury （HILI） tends to have complex toxic material basis and toxic mechanism， which greatly affects the safety of traditional Chinese medicine. This article summarizes the main toxic components of Chinese herbal medicine causing liver injury and their mechanism of action. The toxic components of Chinese herbal medicine causing liver injury can be classified into two categories of drug-derived and non-drug-derived toxic components. Drug-derived toxic components mainly include alkaloids， terpenoids， anthraquinones， and phenylpropanoids， and their mechanism of action involves oxidative stress， apoptosis and necrosis， CYP450 enzymes， and genotoxicity. Non-drug-derived toxic components mainly include pesticide residues， sulfur dioxide residues， heavy metals， fungi， and plant growth regulators， and their mechanisms involve oxidative stress， apoptosis， metabolic disorders， and CYP450 enzymes. On this basis， this article further proposes the unsolved problems and research difficulties， in order to promote the basic research on the hepatotoxicity of traditional Chinese medicine.
- Drugs， Chinese Herbal,
- Chemical and Drug Induced Liver Injury,
- Material Basis

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References(62)

References

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