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Volume 40 Issue 8
Aug.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(8): 1693-1698

Role of ferroptosis in hepatic ischemia-reperfusion injury

DOI: 10.12449/JCH240830

  • Department of Hepatobiliary，Pancreatic and Splenic Surgery，The Affiliated Yantai Hospital of Binzhou Medical University，Yantai，Shandong 264100，China

Research funding:

Shandong Traditional Chinese Medicine Technology Project (2021M160)

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  • Corresponding author: WEI Yong， weiyonglancet@163.com （ORCID： 0000-0002-3279-9465）
  • Received Date: 2023-12-06
  • Accepted Date: 2024-03-20
  • Published Date: 2024-08-25
    Abstract
  • Ferroptosis is a new type of regulatory cell death and is mainly caused by changes in intracellular iron homeostasis due to various inducers， which promotes the occurrence of iron ion-dependent lipid peroxidation， thereby leading to the accumulation of toxic lipid peroxides and finally resulting in cell death. Hepatic ischemia-reperfusion injury is a common and serious complication after liver surgery， with the main mechanisms of anaerobic respiration， mitochondrial injury， oxidative stress response， inflammatory response， calcium overload， and microcirculation dysfunction. This article introduces the concepts and mechanisms of ferroptosis and hepatic ischemia-reperfusion injury and summarizes some related treatment strategies， so as to provide a reference for exploring new treatment methods for hepatic ischemia-reperfusion injury.

     

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