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Volume 40 Issue 8
Aug.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(8): 1704-1708

Molecular mechanism of traditional Chinese medicine active components in regulating glucose metabolism against cholangiocarcinoma

DOI: 10.12449/JCH240832
  • 1a.

    The Third Clinical Medical College，Henan University of Chinese Medicine，Zhengzhou 450046，China

  • 1b.

    School of Medicine，Henan University of Chinese Medicine，Zhengzhou 450046，China

  • 2.

    Department of Oncology，The Third Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450046，China

Research funding:

The Special Project for Scientific Research on Traditional Chinese Medicine in Henan Province (2023ZY2110);

The Training Program for Young Scholars in Universities of Henan Province (2021GGJS084)

More Information
  • Corresponding author: WANG Xiangqi， wangxiangqi777@163.com （ORCID： 0009-0000-9120-1702）
  • Received Date: 2024-01-10
  • Accepted Date: 2024-02-01
  • Published Date: 2024-08-25
    Abstract
  • Cholangiocarcinoma is a highly heterogeneous tumor with an insidious onset， severe conditions， a high degree of malignancy， and an extremely poor prognosis. Glucose is a major energy source for the proliferation and metastasis of cholangiocarcinoma， and the glucose metabolism pathway of cholangiocarcinoma cells will be re-edited in the process of rapid proliferation to produce a large amount of energy for their own needs. Traditional Chinese medicine has unique advantages in the treatment of cholangiocarcinoma， and studies have shown that the active components of traditional Chinese medicine can inhibit the development and progression of cholangiocarcinoma by regulating glucose metabolism. This article reviews the characteristics of glucose metabolism in cholangiocarcinoma and the role of the active components of traditional Chinese medicine in regulating glucose metabolism against cholangiocarcinoma， in order to provide new ideas for the treatment of cholangiocarcinoma.

     

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