The role of CD8<sup>+</sup> T cells in nonalcoholic steatohepatitis

Yiming ZHAO; Kaiyang LI; Mei YANG; Qi ZHAO

doi:10.12449/JCH241026

Volume 40 Issue 10

Oct. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(10): 2087-2091

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The role of CD8⁺ T cells in nonalcoholic steatohepatitis

DOI: 10.12449/JCH241026

Yiming ZHAO¹,
Kaiyang LI¹,
Mei YANG^{2a
,
,
,},
Qi ZHAO^2b

1.
The Second Clinical Medical School of Guizhou University of Traditional Chinese Medicine，Guiyang 550002，China
2a.
Department of Clinical Laboratory，The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine，Guiyang 550001，China
2b.
Department of Gastroenterology，The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine，Guiyang 550001，China

Research funding:

National Natural Science Foundation of China (82160866);

Science and Technology Plan Project of Guizhou Province (Guizhou Science and Technology base-ZK ［2023］ General 433);

Science and Technology Fund of Guizhou Provincial Health Commission (gzwkj2023-208);

Key Laboratory of Higher Education in Guizhou Province (Guizhou Education Technology ［2023］017)

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Corresponding author: YANG Mei， 908417289@qq.com （ORCID： 0009-0003-3563-4767）
Received Date: 2024-01-29
Accepted Date: 2024-03-01
Published Date: 2024-10-25

Abstract

Abstract

Nonalcoholic steatohepatitis （NASH） is a liver disease closely associated with metabolic syndrome， and its pathogenesis includes insulin resistance， lipid metabolism disorders， and inflammatory response. This article briefly describes how CD8⁺ T cells exert a cytotoxic effect through the three pathways of the Fas-Fas ligand signaling pathway， the release of perforin and granzymes， and the secretion of tumor necrosis factor-α and other cytokines， and these mechanisms allow CD8⁺ T cells to specifically kill virus-infected cells and tumor target cells， thereby participating in immune regulation. At the same time， this article summarizes that CD8⁺ T cells promote the recruitment of macrophages cooperate with natural killer T cells to participate in the development of adipose tissue inflammation， and lead to liver injury through automatic attack and epigenetic mechanisms， finally promoting the pathogenesis of NASH. It is concluded that CD8⁺ T cells may become a new therapeutic target for NASH， and in-depth research on the specific mechanism of CD8⁺ T cells affecting the pathogenesis in NASH in the future may help to further guide clinical treatment.
- Non-alcoholic Fatty Liver Disease,
- CD8-Positive T-Lymphocytes,
- Adipose Tissue,
- Inflammation,
- Epigenetics

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References(46)

References

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The role of CD8⁺ T cells in nonalcoholic steatohepatitis

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