Research advances in the mechanism of action of nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome in autoimmune hepatitis

Lifei WANG; Longlong LUO; Guojing XING; Lixia LU; Bin LI; Jiucong ZHANG; Xiaohui YU

doi:10.12449/JCH241027

Volume 40 Issue 10

Oct. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(10): 2092-2097

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Research advances in the mechanism of action of nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome in autoimmune hepatitis

DOI: 10.12449/JCH241027

Lifei WANG^{1, 2},
Longlong LUO^{1, 2},
Guojing XING^{2, 3},
Lixia LU²,
Bin LI²,
Jiucong ZHANG^{2
,
,
,},
Xiaohui YU^{2
,
,
,}

1.
The First Clinical Medical College of Gansu University of Chinese Medicine，Lanzhou 730000，China
2.
Department of Gastroenterology，The 940 Hospital of Joint Logistic Support Force of PLA，Lanzhou 730050，China
3.
Department of Gastroenterology，General Hospital of Ningxia Medical University，Yinchuan 750001，China

Research funding:

Gansu Province Science and Technology Plan Project Assignment (22YF7FA105);

Gansu Province Health Industry Scientific Research Plan Project Contract (GSWSKY2021-054);

Gansu Clinical Medical Research Center for Non-infectious Liver Diseases (21JR7RA017);

Liver Disease Diagnosis and Treatment Center, 940th Hospital Foundation, Joint Logistics Support Force (2021yxky079)

More Information

Corresponding author: ZHANG Jiucong， zhangjiucong@163.com （ORCID： 0000-0003-4006-3033）; YU Xiaohui， yuxiaohui528@126.com （ORCID： 0000-0002-8633-3281）
Received Date: 2024-01-11
Accepted Date: 2024-03-11
Published Date: 2024-10-25

Abstract

Abstract

Autoimmune hepatitis （AIH） is chronic hepatitis caused by the attack of live cells by the immune system， and at present， the pathogenesis of AIH remains unclear. Inflammasomes are important components of innate immunity and are involved in a variety of pathophysiological processes. Studies have shown that inflammatory response associated with nucleotide-binding oligomerization domain-like receptor protein 3 （NLRP3） plays an important role in the pathogenesis of AIH， which mainly mediates the release of proinflammatory factors and pyroptosis， thereby participating in the pathophysiological process of AIH. Therefore， the development and progression of AIH can be delayed by inhibiting the activation of NLRP3 inflammasomes， which provides new ideas for the prevention and treatment of AIH.
- Hepatitis， Autoimmune,
- NLR Family， Pyrin Domain-Containing 3 Protein,
- Therapeutics

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References

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Research advances in the mechanism of action of nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome in autoimmune hepatitis

DOI: 10.12449/JCH241027

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Research advances in the mechanism of action of nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome in autoimmune hepatitis

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