Research advances of noninvasive diagnosis of fibrotic non-alcoholic steatohepatitis

Gong FENG; Rongyao KONG; Jiaxue WANG; Tianyue WU; Xiaohui WU; Juning WANG; Qinqin YAN; Man MI

doi:10.12449/JCH241125

Volume 40 Issue 11

Nov. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(11): 2293-2299

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Research advances of noninvasive diagnosis of fibrotic non-alcoholic steatohepatitis

DOI: 10.12449/JCH241125

Gong FENG^{1a, 2
,
,
,},
Rongyao KONG^1b,
Jiaxue WANG^1b,
Tianyue WU^1c,
Xiaohui WU^1b,
Juning WANG³,
Qinqin YAN^1a,
Man MI^{1a
,
,
,}

1a.
Institute of General Practice，Xi’an Medical University，Xi’an 710021，China
1b.
School of Clinical Medicine，Xi’an Medical University，Xi’an 710021，China
1c.
School of General Practice，Xi’an Medical University，Xi’an 710021，China
2.
Department of Infectious Diseases，The First Affiliated Hospital of Xi’an Jiaotong University，Xi’an 710061，China
3.
School of Medicine，Xi’an Peihua University，Xi’an 710199，China

Research funding:

Projects of Shaanxi Provincial Department of Education (23JK0646);

Natural Science Basic Research Program of Shaanxi (2023-JC-YB-699);

Xi’an Medical University Scientific Research Capacity Enhancement Program (2022NLTS098);

Young Talent Support Program of Xi’an City Association for Science and Technology (959202413081)

More Information

Corresponding author: FENG Gong， 2543073495@qq.com （ORCID： 0000-0001-5394-0029）; MI Man， 853002274@qq.com （ORCID： 0000-0001-7408-5113）
Received Date: 2024-02-01
Accepted Date: 2024-04-19
Published Date: 2024-11-25

Abstract

Abstract

A subset of patients with non-alcoholic fatty liver disease （NAFLD） can progress to nonalcoholic steatohepatitis （NASH）. When NASH reaches a fibrosis degree of F≥2 and a NAS score of≥4， this stage of NASH is referred to as fibrotic NASH， which is a key focus in clinical drug trials. Currently， liver biopsy is the gold standard for assessing the histological changes of the liver， but its clinical application is limited by its invasiveness， and therefore， it is of particular importance to develop noninvasive detection methods for fibrotic NASH. This article summarizes the recent research achievements in novel noninvasive diagnostic methods for fibrotic NASH and elaborates on these new diagnostic methods for predicting fibrotic NASH in terms of current status， challenges faced， and prospects for future development.
- Non-alcoholic Fatty Liver Disease,
- Fibrosis,
- Biomarkers,
- Diagnosis,
- Artificial Intelligence

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References(36)

References

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Research advances of noninvasive diagnosis of fibrotic non-alcoholic steatohepatitis

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Research advances of noninvasive diagnosis of fibrotic non-alcoholic steatohepatitis

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