Immunological mechanism of drug-induced liver injury

Yu WANG; Shuang LI; Chenghai LIU

doi:10.12449/JCH241227

Volume 40 Issue 12

Dec. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(12): 2538-2542

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Immunological mechanism of drug-induced liver injury

DOI: 10.12449/JCH241227

Yu WANG^{1, 2},
Shuang LI¹,
Chenghai LIU^{2, 3
,
,
,}

1.
Department of Gastroenterology，Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine，Shanghai 201999，China
2.
Institute of Liver Diseases，Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai 201203，China
3.
Key Laboratory of Liver and Kidney Diseases of the Ministry of Education，Shanghai Key Laboratory of Traditional Chinese Medicine，Shanghai 201203，China

Research funding:

National Natural Science Foundation of China (82305099);

Supported by Youqing （Yucai） Program of Baoshan District Health and Wellness Committee (BSWSYC-2024-07);

A New Round （2023-2025） of Key Medical Disciplines and Characteristic Brand Building Projects in Baoshan District (BSZK-2023-BZ07)

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Corresponding author: LIU Chenghai， chenghailiu@hotmail.com （ORCID： 0000-0002-1696-6008）
Received Date: 2024-03-27
Accepted Date: 2024-05-10
Published Date: 2024-12-25

Abstract

Abstract

Drug-induced liver injury （DILI） has a complex mechanism involving various pathways with a synergistic effect on each other and a causal relationship with each other， among which immune response plays an important role in the pathogenesis of DILI. In the context of genetic background， drug active metabolites， drug-molecule complexes， and danger signal molecules may be used as the trigger factors for immune response in DILI， activating the mechanism of drug antigenic hypersensitivity， P-i hypothesis， and danger signal mechanism in innate immunity. The cascade reaction of innate immunity and adaptive immunity leads to the imbalance of the innate immune tolerance of the liver and thus causes immunoinflammatory injury of liver tissue. This article mainly elaborates on the immunological mechanism of DILI， in order to provide new ideas for the research and development of therapeutic targets for DILI and the methods for avoiding adverse drug reactions.
- Chemical and Drug Induced Liver Injury,
- Immunity,
- Therapeutics

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References(39)

References

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Immunological mechanism of drug-induced liver injury

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