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Volume 41 Issue 3
Mar.  2025
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Article Navigation >  Journal of Clinical Hepatology  > 2025  >  41(3): 469-477

Effect of Yiqi Yangyin Jiedu Huayu prescription on intestinal metabolites in liver cirrhosis with minimal hepatic encephalopathy： A study based on metabolomics

DOI: 10.12449/JCH250312

  • Department of Integrated Traditional Chinese and Western Medicine，Beijing Ditan Hospital，Capital Medical University，Laboratory for Clinical Medicine，Capital Medical University，Beijing 100015，China

Research funding:

National Natural Science Foundation of China (82104781);

Research and Cultivation Program of Beijing Municipal Hospital (PZ20241802);

Beijing Hospital Management Center “Peak” talent training program (DFL20191803);

High-level Public Health Technical Personnel Construction Project Training Program (Discipline Leader-02-16)

More Information
  • Corresponding author: YANG Zhiyun， yangzhiyun2016@163.com （ORCID： 0000-0002-1522-0749）
  • Received Date: 2024-07-08
  • Accepted Date: 2024-08-12
  • Published Date: 2025-03-25
    Abstract
  •   Objective  To investigate the effect of Yiqi Yangyin Jiedu Huayu prescription on minimal hepatic encephalopathy in liver cirrhosis based on intestinal metabolomics.  Methods  A total of 11 patients with liver cirrhosis who were hospitalized in Beijing Ditan Hospital， Capital Medical University， from March to May 2024， and were diagnosed with MHE based on psychometric hepatic encephalopathy score were enrolled as subjects， and 11 healthy family members of the patients were enrolled as control group. Fecal samples were collected for metabolomics analysis from the control group and the patients with MHE before and after treatment with Yiqi Yangyin Jiedu Huayu prescription， and a population cohort study was conducted to investigate the effect of Yiqi Yangyin Jiedu Huayu prescription on intestinal metabolism of patients with MHE. The Fisher’s exact test was used for categorical data between two groups； the independent samples t-test was used for comparison of normally distributed continuous data between two groups， the paired t-test was used for comparision before and after treatment within the same group， and the Wilcoxon rank-sum test was used for comparison of non-normally distributed continuous data between two groups.  Results  A total of 29 differentially expressed metabolites were detected between the MHE group and the control group， mainly amino acids， organic acids， organic amines， carbohydrates， fatty acids， and vitamins， and there were 12 upregulated metabolites and 17 downregulated metabolites in the MHE group， which were mainly enriched in the metabolic pathways of ornithine， branched-chain amino acid， and aromatic amino acid. After the treatment with Yiqi Yangyin Jiedu Huayu prescription， 80 differentially expressed metabolites were detected in the patients with MHE， mainly carbohydrates， organic acids， and amino acids， and there were 56 upregulated metabolites and 24 downregulated metabolites， which were mainly enriched in the metabolic pathways of ornithine， branched-chain amino acid， and aromatic amino acid.  Conclusion  Yiqi Yangyin Jiedu Huayu prescription can exert a therapeutic effect on patients with MHE by regulating intestinal metabolism.

     

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    • References(18)
  • [1]
    BOHRA A, WORLAND T, HUI S, et al. Prognostic significance of hepatic encephalopathy in patients with cirrhosis treated with current standards of care[J]. World J Gastroenterol, 2020, 26( 18): 2221- 2231. DOI: 10.3748/wjg.v26.i18.2221.
    [2]
    Chinese Society of Hepatology, Chinese Medical Association. Guidelines on the management of hepatic encephalopathy in cirrhosis[J]. J Clin Hepatol, 2018, 34( 10): 2076- 2089. DOI: 10.3969/j.issn.1001-5256.2018.10.007.

    中华医学会肝病学分会. 肝硬化肝性脑病诊疗指南[J]. 临床肝胆病杂志, 2018, 34( 10): 2076- 2089. DOI: 10.3969/j.issn.1001-5256.2018.10.007.
    [3]
    YANG XH, HUANG GC, WANG M, et al. TCM Mechanism of Dahuangjianji retention Enema treating minimal hepatic encephalopathy[J]. Jilin J Tradit Chin Med, 2016, 36( 12): 1220- 1222. DOI: 10.13463/j.cnki.jlzyy.2016.12.011.

    杨小徽, 黄国初, 王萌, 等. 大黄煎剂保留灌肠治疗轻微型肝性脑病[J]. 吉林中医药, 2016, 36( 12): 1220- 1222. DOI: 10.13463/j.cnki.jlzyy.2016.12.011.
    [4]
    ZHANG GG. Effect of rhubarb decoction retention Enema on endotoxin and blood ammonia levels in the treatment of mild hepatic encephalopathy[J]. J Pract Tradit Chin Med, 2018, 34( 5): 523- 524. DOI: 10.3969/j.issn.1004-2814.2018.05.013.

    张贵格. 大黄煎剂保留灌肠治疗轻微型肝性脑病对内毒素及血氨水平的影响[J]. 实用中医药杂志, 2018, 34( 5): 523- 524. DOI: 10.3969/j.issn.1004-2814.2018.05.013.
    [5]
    JIANG TT, YANG ZY, WANG XB, et al. Clinical efficacy of Yiqi Yangyin Jiedu Huayu formula modifications combined with western medicine in the treatment of minimal hepatic encephalopathy based on the stroop test[J]. J Tradit Chin Med, 2023, 64( 5): 490- 497. DOI: 10.13288/j.11-2166/r.2023.05.011.

    姜婷婷, 杨志云, 王宪波, 等. 基于Stroop测试探讨益气养阴解毒化瘀方加减联合西药治疗轻微型肝性脑病的临床疗效[J]. 中医杂志, 2023, 64( 5): 490- 497. DOI: 10.13288/j.11-2166/r.2023.05.011.
    [6]
    MANCINI A, CAMPAGNA F, AMODIO P, et al. Gut: Liver: Brain axis: The microbial challenge in the hepatic encephalopathy[J]. Food Funct, 2018, 9( 3): 1373- 1388. DOI: 10.1039/c7fo01528c.
    [7]
    American Association for the Study of Liver Diseases, European Association for the Study of the Liver. Hepatic encephalopathy in chronic liver disease: 2014 practice guideline by the European association for the study of the liver and the American association for the study of liver diseases[J]. J Hepatol, 2014, 61( 3): 642- 659. DOI: 10.1016/j.jhep.2014.05.042.
    [8]
    LI SW, WANG K, YU YQ, et al. Psychometric hepatic encephalopathy score for diagnosis of minimal hepatic encephalopathy in China[J]. World J Gastroenterol, 2013, 19( 46): 8745- 8751. DOI: 10.3748/wjg.v19.i46.8745.
    [9]
    DHAREL N, BAJAJ JS. Definition and nomenclature of hepatic encephalopathy[J]. J Clin Exp Hepatol, 2015, 5( Suppl 1): S37- S41. DOI: 10.1016/j.jceh.2014.10.001.
    [10]
    RIDOLA L, NARDELLI S, GIOIA S, et al. Quality of life in patients with minimal hepatic encephalopathy[J]. World J Gastroenterol, 2018, 24( 48): 5446- 5453. DOI: 10.3748/wjg.v24.i48.5446.
    [11]
    RAKOSKI MO, MCCAMMON RJ, PIETTE JD, et al. Burden of cirrhosis on older Americans and their families: Analysis of the health and retirement study[J]. Hepatology, 2012, 55( 1): 184- 191. DOI: 10.1002/hep.24616.
    [12]
    YAO C, YAO F, XIE W, et al. Clinical observation on rhubarb decoction retention Enema in treatment of minimal hepatic encephalopathy[J]. Liaoning J Tradit Chin Med, 2013, 40( 3): 474- 476. DOI: 10.13192/j.ljtcm.2013.03.96.yaoch.089.

    姚春, 姚凡, 谢武, 等. 大黄煎剂保留灌肠治疗轻微肝性脑病临床研究[J]. 辽宁中医杂志, 2013, 40( 3): 474- 476. DOI: 10.13192/j.ljtcm.2013.03.96.yaoch.089.
    [13]
    YAO C, WANG M, HUANG GC, et al. Effect of the detoxification and dissipation blood stasis formula on quality of life and syndrome of traditional Chinese medicine in hepatic cirrhosis with minimal hepatic encephalopathy[J]. Guangming J Chin Med, 2014, 29( 6): 1175- 1178. DOI: 10.3969/j.issn.1003-8914.2014.06.029.

    姚春, 王萌, 黄国初, 等. 解毒化瘀方对肝硬化轻微型肝性脑病患者生存质量及中医证候的影响[J]. 光明中医, 2014, 29( 6): 1175- 1178. DOI: 10.3969/j.issn.1003-8914.2014.06.029.
    [14]
    WANG MG, WANG N, MAO DW, et al. The clinical research into minimal hepatic encephalopathy treated with Liuwei xingshen granule[J]. Henan Tradit Chin Med, 2016, 36( 12): 2112- 2114. DOI: 10.16367/j.issn.1003-5028.2016.12.0843.

    王明刚, 王娜, 毛德文, 等. 六味醒神颗粒治疗轻微型肝性脑病临床研究[J]. 河南中医, 2016, 36( 12): 2112- 2114. DOI: 10.16367/j.issn.1003-5028.2016.12.0843.
    [15]
    GOMAA EZ. Human gut microbiota/microbiome in health and diseases: A review[J]. Antonie Van Leeuwenhoek, 2020, 113( 12): 2019- 2040. DOI: 10.1007/s10482-020-01474-7.
    [16]
    LONG LY, HUANG Y. Research progress on astrocyte and microglia in the pathogenesis of hepatic encephalopathy[J/CD]. Chin J Liver Dis Electron Version, 2023, 15( 3): 28- 33. DOI: 10.3969/j.issn.1674-7380.2023.03.005.

    龙丽媛, 黄燕. 星形胶质细胞和小胶质细胞在肝性脑病发病机制中研究进展[J/CD]. 中国肝脏病杂志(电子版), 2023, 15( 3): 28- 33. DOI: 10.3969/j.issn.1674-7380.2023.03.005.
    [17]
    KAWAGUCHI T, TANIGUCHI E, SATA M. Effects of oral branched-chain amino acids on hepatic encephalopathy and outcome in patients with liver cirrhosis[J]. Nutr Clin Pract, 2013, 28( 5): 580- 588. DOI: 10.1177/0884533613496432.
    [18]
    GLUUD LL, DAM G, LES I, et al. Branched-chain amino acids for people with hepatic encephalopathy[J]. Cochrane Database Syst Rev, 2017, 5( 5): CD001939. DOI: 10.1002/14651858.CD001939.pub4.
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