Effect of intestinal flora and metabolites on the development and progression of acute-on-chronic liver failure

Ke SHI; Qun ZHANG; Xianbo WANG; Ying FENG

doi:10.12449/JCH250327

Volume 41 Issue 3

Mar. 2025

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Article Navigation > Journal of Clinical Hepatology > 2025 > 41(3): 568-573

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Effect of intestinal flora and metabolites on the development and progression of acute-on-chronic liver failure

DOI: 10.12449/JCH250327

Center of Integrative Medicine，Beijing Ditan Hospital，Capital Medical University，Beijing 100015，China

Research funding:

Construction Project of High-level Key Disciplines of Traditional Chinese Medicine of National Administration of Traditional Chinese Medicine (zyyzdxk-202300);

Capital’‍s Funds for Health mprovement and Research (CFH2024-1-2173);

Seventh Batch of National Traditional Chinese Medicine Experts Academic Experience Inheritance Program ;

Beijing Traditional Chinese Medicine Technology Development Fund Project (BJZYYB-2023-06);

Beijing Municipal Natural Science Foundation (7232272)

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Corresponding author: WANG Xianbo， wangxianbo638@163.com （ORCID： 00‍00-0002-3593-5741）
Received Date: 2024-06-30
Accepted Date: 2024-08-14
Published Date: 2025-03-25

Abstract

Abstract

Acute-on-chronic liver failure （ACLF） is a dangerous disease with severe conditions， rapid progression， and high short-term mortality. Intestinal flora and metabolites are closely associated with the development， progression， and pathogenesis of ACLF. During the development of ACLF， the destruction of intestinal integrity and the dysregulation of intestinal microecology and its metabolites mediate immune disturbance and thus aggravate systemic inflammatory response. This article elaborates on the role of intestinal flora and metabolites in the development and progression of ACLF and related therapeutic strategies.
- Gastrointestinal Microbiome,
- Metabolism,
- Acute-On-Chronic Liver Failure

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Effect of intestinal flora and metabolites on the development and progression of acute-on-chronic liver failure

DOI: 10.12449/JCH250327

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Effect of intestinal flora and metabolites on the development and progression of acute-on-chronic liver failure

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