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CN 22-1108/R
Volume 41 Issue 12
Dec.  2025
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Article Navigation >  Journal of Clinical Hepatology  > 2025  >  41(12): 2499-2505

Change in psychological state and its influencing factors in chronic hepatitis B patients during long-term antiviral treatment

DOI: 10.12449/JCH251210

  • Department of Infectious Diseases，Nanfang Hospital，Southern Medical University，Guangzhou 510515，China

Research funding:

Guangdong Medical Science and Technology Research Fund (C2022077)

More Information
  • Corresponding author: YIN Junhua， 576334096@qq.com （ORCID： 0009-0001-8702-8406）
  • Received Date: 2025-06-23
  • Accepted Date: 2025-07-29
  • Published Date: 2025-12-25
    Abstract
  •   Objective  To investigate the change in psychological state， especially depression， anxiety， and fatigue， among chronic hepatitis B （CHB） patients undergoing long-term nucleos（t）ide analogue （NA） antiviral therapy， as well as related influencing factors， and to provide evidence-based data for developing individualized long-term psychological intervention regimens.  Methods  A total of 118 CHB patients who were followed up at the outpatient service of Department of Infectious Diseases， Nanfang Hospital， Southern Medical University， from January 2020 to December 2022 were enrolled， and all patients received NA treatment. Self-Rating Depression Scale （SDS）， Self-Rating Anxiety Scale （SAS）， and Multidimensional Fatigue Inventory-20 （MFI-20） were used to assess the psychological state of patients before treatment and after 104 weeks of antiviral therapy. The independent-samples t test was used for comparison of continuous data between two groups， and the chi-square test was used for comparison of categorical data between two groups. The logistic regression model was used to identify independent influencing factors for the alleviation of fatigue， anxiety， and depression.  Results  After 104 weeks of treatment， there were significant reductions in total fatigue score （from 54.05±13.34 to 46.79±13.33）， anxiety score （from 48.16±9.18 to 34.08±7.36）， and depression score （from 60.27±9.94 to 43.69±9.64） （all P<0.05）. The multivariate analysis showed that liver cirrhosis （odds ratio ［OR］=0.410， 95%CI：0.169 — 0.995，P=0.049） and a family history of hepatocellular carcinoma （HCC） （OR=0.146， 95%CI：0.041 — 0.525，P=0.003） were independent risk factors for poor fatigue relief； female sex （OR=0.094， 95%CI：0.010 — 0.864，P=0.037）， a relatively low education level （OR=0.155， 95%CI：0.028 — 0.860，P=0.033）， and a family history of HCC （OR=0.015， 95%CI：0.002 — 0.109，P<0.001） were independent risk factors for poor alleviation of anxiety； female sex （OR=0.050， 95%CI：0.006 — 0.391，P=0.004） and a family history of HCC （OR=0.091， 95%CI：0.019 — 0.444，P=0.003） were independent risk factors for poor alleviation of depression.  Conclusion  There is a tendency of reduction in the degree of fatigue， anxiety， and depression in CHB patients during long-term antiviral therapy， suggesting that antiviral therapy has a certain effect in improving psychological state. However， female patients and the patients with a family history of liver cancer tend to experience a heavier psychological burden， and such patients should be taken seriously in clinical practice and receive individualized psychological support and intervention.

     

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