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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 41 Issue 12
Dec.  2025
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Article Navigation >  Journal of Clinical Hepatology  > 2025  >  41(12): 2661-2666

Molecular mechanisms of liver regeneration and its therapeutic potential in the context of liver failure

DOI: 10.12449/JCH251231

  • Beijing YouAn Hospital，Capital Medical University，Beijing Institute of Hepatology，Beijing 100069，China

Research funding:

National Natural Science Foundation of China (81770611);

National Natural Science Foundation of China (82002243);

Key Project of Beijing Natural Science Foundation and Beijing Municipal Education Commission (KZ202010025035);

Capita’s Health Development Research Special Fund Key Project (Shoufa 2020-1-1151);

Beijing Science and Technology Program “Capital Clinical Diagnosis and Treatment Technology Research and Demonstration Application”Special Project (Z191100006619096);

Beijing Science and Technology Program “Capital Clinical Diagnosis and Treatment Technology Research and Demonstration Application”Special Project (Z191100006619097);

Beijing Hospital Management Center “Seedling Plan” Special Fund (QML20201702);

Beijing Municipal Administration of Hospitals “Peak Climbing” Talent Program (DFL20221503);

High-level Public Health Technology Talent Construction Project (Disciplinary Leader-02-13)

More Information
  • Corresponding author: REN Feng， renfeng7512@ccmu.edu.cn （ORCID： 0000-0001-7736-8637）
  • Received Date: 2025-05-07
  • Accepted Date: 2025-07-07
  • Published Date: 2025-12-25
    Abstract
  • Liver failure is a clinical syndrome in which the speed of hepatocyte necrosis exceeds the self-repair capacity of the liver and is caused by various pathogenic factors， posing a serious threat to human health. Due to the complex pathogenesis， high incidence rate， and high mortality rate of liver failure and a lack of effective treatment methods， the treatment of liver failure remains a global challenge and a difficult issue. As an important mechanism by which the liver responds to liver injury， liver regeneration is one of the key factors for successful treatment of liver failure patients and plays a vital role in the development and prognosis of liver failure. Liver regeneration is an extremely complex biological process involving multiple cytokines and transcription factors， which jointly promote hepatocyte proliferation and tissue repair by activating various signaling pathways. This article systematically reviews the molecular mechanism of liver regeneration in liver failure， emphasizes the key role of cytokines （such as interleukin-6， tumor necrosis factor-α， and hepatocyte growth factor） and related signaling pathways in regulating hepatocyte proliferation and tissue repair， and explores the therapeutic potential of liver regeneration in the context of liver failure， in order to provide a reference for the basic research on liver regeneration in liver failure.

     

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