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CN 22-1108/R
Volume 42 Issue 8
Aug.  2026
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Article Navigation >  Journal of Clinical Hepatology  > 2026  >  42(8): 1766-1772

Research advances in animal models of acute-on-chronic liver failure: From two-stage modeling to three-stage full-course simulation

DOI: 10.12449/JCH260805

  • Department of Infectious Diseases，Ruijin Hospital，Shanghai Jiao Tong University School of Medicine，Shanghai 200025，China

Research funding:

National Natural Science Foundation of China (82570730);

National Natural Science Foundation of China (82170619);

National Natural Science Foundation of China (81970544);

Shanghai Oriental Talents Program Top-notch Talent Project (BJJY2024072);

Project for Discipline Leaders in the Three-year Action Plan （2023—2025） for Strengthening the Construction of Public Health System in Shanghai (GWVI-11.2-XD03)

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  • Corresponding author: Xiang Xiaogang， shine-xxg@163.com（ORCID： 0000-0003-0999-2950）
  • Received Date: 2026-05-14
  • Accepted Date: 2026-08-05
  • Published Date: 2026-08-25
    Abstract
  • Acute-on-chronic liver failure （ACLF） is a severe clinical syndrome characterized by acute decompensation of liver function， extrahepatic organ injury， and a high short-term mortality rate， with a complex pathogenesis that has not yet been fully clarified. Animal models of ACLF play a crucial role in disease research， since they not only provide a solid foundation for mechanistic studies， but also offer experimental evidence for clinical practice， thereby helping to promote advances in diagnosis and treatment. This article systematically reviews the commonly used animal models of ACLF， compares the establishment methods， pathophysiological characteristics， advantages， and limitations of different models， and discusses the latest research advances in animal models and innovative therapeutic strategies in the field， in order to provide a reference for further optimization， standardization， and application of animal models for ACLF.

     

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