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CN 22-1108/R
Volume 42 Issue 8
Aug.  2026
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Article Navigation >  Journal of Clinical Hepatology  > 2026  >  42(8): 1790-1798

Expert consensus on the clinical classification of acute-on-chronic liver failure （2026 edition）

DOI: 10.12449/JCH260809
Research funding:

Capital’s Funds for the Health Improvement and Research (2024-1-2181)

  • Received Date: 2026-06-18
  • Accepted Date: 2026-07-17
  • Published Date: 2026-08-25
    Abstract
  • Acute-on-chronic liver failure （ACLF） is characterized by marked heterogeneity and potential reversibility and thus requires refined clinical classification to achieve precise diagnosis and treatment. Establishing a scientific， standardized， simple， and practical clinical classification system is of great importance for disease assessment， prognostic evaluation， therapeutic decision-making， and stratified management. Based on the actual needs of the clinical diagnosis and treatment of ACLF in China and with reference to related guidelines， evidence-based medical evidence， and expert opinion in China and globally， this consensus summarizes the methods for ACLF classification and their application in clinical practice， in order to improve clinical identification and stratified diagnosis and treatment， promote precise diagnosis and treatment， and ultimately improve the prognosis of patients.

     

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