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Volume 42 Issue 8
Aug.  2026
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Article Navigation >  Journal of Clinical Hepatology  > 2026  >  42(8): 1985-1989

Role and mechanism of liver sinusoidal endothelial cells in acetaminophen-induced liver injury

DOI: 10.12449/JCH260836
  • 1.

    Department of Infectious Diseases，Peking University First Hospital，Beijing 100034，China

  • 2.

    Department of Physiology and Pathophysiology，School of Basic Medical Sciences，Capital Medical University，Beijing 100069，China

  • 3.

    Department of Clinical Laboratory，Beijing Chaoyang Hospital，Capital Medical University，Beijing 100024，China

Research funding:

National Natural Science Foundation of China (81870417);

National Natural Science Foundation of China (82070605)

More Information
  • Corresponding author: Wang Yan， wangyanwang@bjmu.edu.cn （ORCID： 0000-0002-8577-0527）
  • Received Date: 2025-11-21
  • Accepted Date: 2026-01-21
  • Published Date: 2026-08-25
    Abstract
  • Liver injury due to acetaminophen overdose is one of the main causes of acute liver failure， with a complex pathogenesis. In this process， liver sinusoidal endothelial cell （LSEC） injury is a key early event jointly mediated by factors such as oxidative stress， cell apoptosis， and imbalance between fibrinolysis and coagulation. Subsequent LSEC dysfunction further induces sinusoidal microcirculatory disturbances， amplifies the inflammatory response， impairs the regeneration and repair abilities of the liver， and finally causes hepatocyte necrosis. This article systematically elaborates on the critical role and molecular mechanism of LSEC in acetaminophen-induced liver injury， in order to provide a theoretical basis for novel therapeutic strategies and research directions.

     

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