Liver function is an important influential factor for the treatment outcome and prognosis of patients with hepatocellular carcinoma (HCC) following radiofrequency ablation (RFA) and should be evaluated before operation. In order to demonstrate the clinical significance of liver function evaluation before RFA, The values of some liver function indices, such as Child-Turcotte-Pugh (CTP) score, Model for End-stage Liver Disease (MELD) score, prothrombin time, prothrombin activity, platelet count, serum albumin, bilirubin level, and hepatitis B virus DNA level were summarized, in predicting the complications and survival in HCC patients after RFA.