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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 2
Feb.  2014
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Article Contents

Meta- analysis of association between cholecystectomy and colorectal adenoma

DOI: 10.3969/j.issn.1001-5256.2014.02.016
  • Received Date: 2013-06-25
  • Published Date: 2014-02-20
  • Objective Patients with a history of cholecystectomy have been thought to be the high- risk population in early colorectal cancer screening in China. However, there are relatively few studies on the association between cholecystectomy and colorectal adenoma ( precancerous lesions of colorectal cancer) around the world. The aim of this paper is to comprehensively evaluate the studies on the relationship between cholecystectomy and colorectal adenoma published both at home and abroad by meta- analysis. Methods Thirteen studies which met the inclusion criteria were divided into cohort study group ( n = 6) and case- control study group ( n = 7) according to research methods. A meta- analysis was performed using Review manager 5. 2 software to calculate the relative risk ( RR) of the cohort study group and the odds ratio ( OR) of the case- control study group, as well as their 95% confidence intervals ( CI) . Results A total of 5940 cases and 158 995 cases were included in the cohort study group and case- control group, respectively. The meta- analysis revealed a positive association between cholecystectomy and colorectal adenoma ( RR = 1. 32, 95% CI: 1. 07- 1. 61; OR = 1. 17, 95% CI: 1. 08- 1. 26) . Conclusion Cholecystectomy leads to an increase in the risk of colorectal adenoma.

     

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